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    eIF3i eukaryotic translation initiation factor 3 subunit i [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF3iprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015834
    Locus tag
    Dmel_CG8882
    See related
    AllianceGenome:FB:FBgn0015834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8882; Dmel\CG8882; DmTRIP; eIF-3beta; eIF-3i; eIF3-S2; SN2-9; Trip1; TRIP1
    Summary
    Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in adult head; adult heart; organism; and ovary. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF3i in Genome Data Viewer
    Location:
    25B5-25B5; 2-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4966367..4967775, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4966367..4967775, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Marcal1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43824 Neighboring gene uncharacterized protein Neighboring gene Synthesis of cytochrome c oxidase Neighboring gene RNA polymerase I and III subunit C Neighboring gene lethal (2) 05714

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes. Yao P, et al. Genome Biol, 2011 Jul 25. PMID 21787382, Free PMC Article
    2. eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells. Song Z, et al. Nucleic Acids Res, 2022 Nov 11. PMID 36330957, Free PMC Article
    3. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article
    4. eIF4A inactivates TORC1 in response to amino acid starvation. Tsokanos FF, et al. EMBO J, 2016 May 17. PMID 26988032, Free PMC Article
    5. The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation. Andersen DS, et al. J Biol Chem, 2007 May 18. PMID 17392269

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit i
    Names
    CG8882-PA
    Trip1
    eIF3i-PA
    suppressor of NA9 2-9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4966367..4967775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078754.4 → NP_523478.1  eukaryotic translation initiation factor 3 subunit i [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02195, Q540Y6, Q9VMX5
      Related
      FBpp0078689
      Conserved Domains (3) summary
      COG2319
      Location:9 → 313
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 50
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:6 → 313
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02195.1 O02195

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