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    Itgbn Integrin betanu subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itgbnprovided by FlyBase
    Official Full Name
    Integrin betanu subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010395
    Locus tag
    Dmel_CG1762
    See related
    AllianceGenome:FB:FBgn0010395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beta integrin; beta-Integrin; beta-nu; betagr;-nu; betaInt; betaInt nu; betaInt-&ngr; betaInt-nu; betaInt[nu]; betanu; betav; betaV-integrin; beta[nu]-integrin; beta[v]integrin; Beta[[nu]]; beta[[v]]; CG1762; CT5192; Dmel\CG1762; Fly betanu; intbetanu; integrin betaPs; Integrinbetanu; ITGbeta PSv; Itgbetanu; Itgbetav
    Summary
    Enables protein heterodimerization activity. Involved in several processes, including melanotic encapsulation of foreign target; muscle cell cellular homeostasis; and negative regulation of synaptic assembly at neuromuscular junction. Located in membrane. Part of integrin complex. Is expressed in several structures, including gastric caecum; gut section; and midgut imaginal island. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4); ITGB8 (integrin subunit beta 8); and ITGBL1 (integrin subunit beta like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Itgbn in Genome Data Viewer
    Location:
    39A1-39A1; 2-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21053033..21058044)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21053033..21058044)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44606 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene torn and diminished rhabdomeres

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melanogaster. Yee GH, et al. Development, 1993 Jul. PMID 8076521
    2. Protective effects of Phaseolus vulgaris lectin against viral infection in Drosophila. Ekowati H, et al. Drug Discov Ther, 2017. PMID 29332891
    3. Role for phagocytosis in the prevention of neoplastic transformation in Drosophila. Zhang M, et al. Genes Cells, 2020 Oct. PMID 32865275
    4. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. Lee JY, et al. J Neurosci, 2017 Mar 22. PMID 28219985, Free PMC Article
    5. Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells. Pert M, et al. Biol Open, 2015 Jan 23. PMID 25617422, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. integrin betanu serves as a phagocytosis receptor responsible for the clearance of apoptotic cells in Drosophila, independent of Draper
      Title: Integrin βν-mediated phagocytosis of apoptotic cells in Drosophila embryos.
    2. that integrin alphaPS3/betanu serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes.
      Title: Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila.
    3. Draper and integrin betanu cooperate in the phagocytic elimination of S. aureus by recognizing distinct cell wall components
      Title: Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila.
    4. Mutagenesis of the integrin cytoplasmic domain, within the chimera, showed the dominant-negative inhibition was not due to talin sequestration alone and that additional interactions are required.
      Title: Multiple factors contribute to integrin-talin interactions in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21057274-21057562 mobile_element_type = transposon:INE-1{}5354

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of integrin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of integrin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin betanu subunit
    Names
    CG1762-PA
    CG1762-PB
    Itgbn-PA
    Itgbn-PB
    beta-Integrin-nu
    beta[[nu]]Integrin
    beta[nu] integrin
    beta[v]integrin
    betanu integrin
    betanuintegrin
    betav integrin
    integrin
    integrin BetaPS
    integrin beta neu
    integrin beta v
    integrin betanu
    integrin bn
    integrinbetanu

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21053033..21058044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078884.3 → NP_523608.2  integrin betanu subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523608.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UN88, Q27591, Q9VIG7
      UniProtKB/TrEMBL
      A0A0S0WGT1, F0JAH6
      Related
      FBpp0080990
      Conserved Domains (3) summary
      smart00187
      Location:38 → 460
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07974
      Location:524 → 552
      EGF_2; EGF-like domain
      pfam08725
      Location:748 → 785
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    2. NM_001316404.1 → NP_001303333.1  integrin betanu subunit, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UN88, Q27591, Q9VIG7
      UniProtKB/TrEMBL
      A0A0S0WGT1, F0JAH6
      Conserved Domains (3) summary
      smart00187
      Location:38 → 460
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07974
      Location:524 → 552
      EGF_2; EGF-like domain
      pfam08725
      Location:748 → 785
      Integrin_b_cyt; Integrin beta cytoplasmic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WGT1 A0A0S0WGT1
    Q27591.2 Q27591
    Q3YNE6 Q3YNE6
    Q3YNE7 Q3YNE7

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