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    SF1 Splicing factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SF1provided by FlyBase
    Official Full Name
    Splicing factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0025571
    Locus tag
    Dmel_CG5836
    See related
    AllianceGenome:FB:FBgn0025571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg5836; CG5836; Dmel\CG5836; dSF1; p70
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of mRNA splicing, via spliceosome. Located in nucleus. Part of precatalytic spliceosome. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SF1 in Genome Data Viewer
    Location:
    90B4-90B4; 3-61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17540421..17545148)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13366143..13370870)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lethal (3) 07882 Neighboring gene Pyrroline-5-carboxylate reductase-like 2 Neighboring gene Peroxiredoxin 3 Neighboring gene H6-like-homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Organization of the Drosophila melanogaster SF1 insulator and its role in transcription regulation in transgenic lines]. Leman DV, et al. Genetika, 2014 Apr. PMID 25715441
    2. A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. Kennedy CF, et al. Mol Cell Biol, 1998 Sep. PMID 9710626, Free PMC Article
    3. Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability. Mazroui R, et al. RNA, 1999 Dec. PMID 10606272, Free PMC Article
    4. Unraveling cis-regulatory mechanisms at the abdominal-A and Abdominal-B genes in the Drosophila bithorax complex. Akbari OS, et al. Dev Biol, 2006 May 15. PMID 16545794
    5. A genome-wide survey of RS domain proteins. Boucher L, et al. RNA, 2001 Dec. PMID 11780626, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The studies performed did not confirm the ability of the SF1 insulator to protect expression of reporter gene white from the chromosome position effect in transgenic lines.
      Title: [Organization of the Drosophila melanogaster SF1 insulator and its role in transcription regulation in transgenic lines].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    splicing factor 1
    Names
    CG5836-PA
    CG5836-PB
    CG5836-PC
    SF1-PA
    SF1-PB
    SF1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17540421..17545148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079915.3 → NP_524654.2  splicing factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524654.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEJ1
      Related
      FBpp0082897
      Conserved Domains (3) summary
      COG5176
      Location:253 → 512
      MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
      cd02395
      Location:392 → 510
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16275
      Location:274 → 385
      SF1-HH; Splicing factor 1 helix-hairpin domain

    2. NM_001275744.1 → NP_001262673.1  splicing factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGU8
      Conserved Domains (1) summary
      pfam16275
      Location:274 → 308
      SF1-HH; Splicing factor 1 helix-hairpin domain

    3. NM_001275743.2 → NP_001262672.1  splicing factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG60
      Conserved Domains (1) summary
      pfam16275
      Location:274 → 334
      SF1-HH; Splicing factor 1 helix-hairpin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG60 A0A0B4KG60
    A0A0B4KGU8 A0A0B4KGU8
    Q95S23 Q95S23
    Q9U1J9 Q9U1J9
    Q9VEJ1 Q9VEJ1

    Gene LinkOut

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