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    CG2663 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2663provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037323
    Locus tag
    Dmel_CG2663
    See related
    AllianceGenome:FB:FBgn0037323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2663
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head and embryonic/larval tracheal section. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2663 in Genome Data Viewer
    Location:
    83A1-83A1; 3-47.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5400594..5404135, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1226316..1229857, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Arginine-TCG 4-1 Neighboring gene krotzkopf verkehrt Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 83a Neighboring gene Odorant receptor co-receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Wang M, et al. Dev Cell, 2022 May 23. PMID 35512700
    2. Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease. Vartiainen S, et al. Dis Model Mech, 2014 Jun. PMID 24812436, Free PMC Article
    3. Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes. Klebes A, et al. Development, 2005 Aug. PMID 16077094
    4. Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes. Ibrahim DM, et al. G3 (Bethesda), 2013 Aug 7. PMID 23749451, Free PMC Article
    5. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Zou S, et al. Proc Natl Acad Sci U S A, 2000 Dec 5. PMID 11095759, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2663-PA
    CG2663-PC
    alpha tocopherol transfer protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5400594..5404135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169053.3 → NP_730931.1  uncharacterized protein Dmel_CG2663, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRE6, Q8I099, Q9VNB4
      Related
      FBpp0078439
      Conserved Domains (2) summary
      smart01100
      Location:28 → 74
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:95 → 250
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_141278.3 → NP_649535.2  uncharacterized protein Dmel_CG2663, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649535.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRE6, Q8I099, Q9VNB4
      Conserved Domains (2) summary
      smart01100
      Location:28 → 74
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:95 → 250
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JRE6 Q7JRE6
    Q8I099 Q8I099

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