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    Nepl6 Neprilysin-like 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl6provided by FlyBase
    Official Full Name
    Neprilysin-like 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0259716
    Locus tag
    Dmel_CG42370
    See related
    AllianceGenome:FB:FBgn0259716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13981; CG33295; CG42370; CG9508; CG9511; CT26920; Dmel\CG42370
    Old locus tag
    Dmel_CG9508; Dmel_CG9511
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl6 in Genome Data Viewer
    Location:
    26C4-26D1; 2-20 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6383435..6385512, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6383435..6385512, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene slow as molasses Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tiggrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. Sun X, et al. Cell Rep, 2014 Sep 25. PMID 25220459, Free PMC Article
    2. Function and dynamics of slam in furrow formation in early Drosophila embryo. Acharya S, et al. Dev Biol, 2014 Feb 15. PMID 24368071
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812
    5. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 6
    Names
    CG42370-PA
    Dmel_CG42370
    Nepl6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6383435..6385512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135179.4 → NP_609023.3  Neprilysin-like 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609023.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VME2
      Conserved Domains (1) summary
      cd08662
      Location:42 → 653
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VME2 Q9VME2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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