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    Pat1 Protein interacting with APP tail-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pat1provided by FlyBase
    Official Full Name
    Protein interacting with APP tail-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029878
    Locus tag
    Dmel_CG10695
    See related
    AllianceGenome:FB:FBgn0029878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10695; Dmel\CG10695; pat1; PAT1
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in pole plasm oskar mRNA localization and regulation of microtubule-based movement. Part of kinesin complex. Is expressed in adult brain; organism; and ovary. Orthologous to human APPBP2 (amyloid beta precursor protein binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pat1 in Genome Data Viewer
    Location:
    6C1-6C1; 1-18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6590776..6596954)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6484809..6490987)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43832 Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 7 Neighboring gene pickled eggs Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wolbachia and host germline components compete for kinesin-mediated transport to the posterior pole of the Drosophila oocyte. Russell SL, et al. PLoS Pathog, 2018 Aug. PMID 30110391, Free PMC Article
    2. Klar ensures thermal robustness of oskar localization by restraining RNP motility. Gaspar I, et al. J Cell Biol, 2014 Jul 21. PMID 25049271, Free PMC Article
    3. Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. Ganguly S, et al. Proc Natl Acad Sci U S A, 2012 Sep 18. PMID 22949706, Free PMC Article
    4. Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Loiseau P, et al. Development, 2010 Aug. PMID 20630947, Free PMC Article
    5. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule-based movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein interacting with APP tail-1
    Names
    CG10695-PA
    CG10695-PB
    CG10695-PC
    Pat1-PA
    Pat1-PB
    Pat1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6590776..6596954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132100.5 → NP_572328.1  protein interacting with APP tail-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3Y7
      Related
      FBpp0070906
      Conserved Domains (4) summary
      sd00006
      Location:518 → 546
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:517 → 553
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:516 → 590
      TPR_12; Tetratricopeptide repeat
      cl10012
      Location:53 → 110
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    2. NM_001272357.2 → NP_001259286.1  protein interacting with APP tail-1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3Y7
      Conserved Domains (4) summary
      sd00006
      Location:518 → 546
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:517 → 553
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:516 → 590
      TPR_12; Tetratricopeptide repeat
      cl10012
      Location:53 → 110
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    3. NM_001272356.2 → NP_001259285.1  protein interacting with APP tail-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259285.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGT5
      Conserved Domains (4) summary
      sd00006
      Location:518 → 546
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:517 → 553
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:516 → 590
      TPR_12; Tetratricopeptide repeat
      cl10012
      Location:53 → 110
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGT5 M9PGT5
    Q9W3Y7 Q9W3Y7

    Gene LinkOut

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