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    qkr58E-1 quaking related 58E-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qkr58E-1provided by FlyBase
    Official Full Name
    quaking related 58E-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0022986
    Locus tag
    Dmel_CG3613
    See related
    AllianceGenome:FB:FBgn0022986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3613; Dmel\CG3613; qkr-58-E; Qkr58E-1; QKR58E-1; qrk58E-1; qrk58E1
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult brain cell body rind; adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See qkr58E-1 in Genome Data Viewer
    Location:
    58D8-58D8; 2-99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22412556..22415518, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18300061..18303023, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene quaking related 58E-3 Neighboring gene Ventrally-expressed protein D Neighboring gene DNA polymerase epsilon subunit 4 Neighboring gene antisense RNA:CR45152 Neighboring gene quaking related 58E-2 Neighboring gene mitochondrial ribosomal protein S29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of Drosophila genes encoding quaking-related maxi-KH domains. Fyrberg C, et al. Biochem Genet, 1998 Feb. PMID 9562906
    2. Comprehensive analysis of nucleocytoplasmic dynamics of mRNA in Drosophila cells. Chen T, et al. PLoS Genet, 2017 Aug. PMID 28771467, Free PMC Article
    3. m(6)A modulates neuronal functions and sex determination in Drosophila. Lence T, et al. Nature, 2016 Dec 8. PMID 27919077
    4. Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Bajpe PK, et al. Mol Cell Biol, 2008 Mar. PMID 18160715, Free PMC Article
    5. Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila. Stoiber MH, et al. Genome Res, 2015 Nov. PMID 26294687, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    quaking related 58E-1
    Names
    CG3613-PA
    CG3613-PC
    CG3613-PD
    KH-domain
    qkr58E-1-PA
    qkr58E-1-PC
    qkr58E-1-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22412556..22415518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299793.1 → NP_001286722.1  quaking related 58E-1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG88, O44435
      Conserved Domains (1) summary
      cd02395
      Location:115 → 236
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

    2. NM_079085.5 → NP_523809.2  quaking related 58E-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523809.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44435, Q9W255
      Related
      FBpp0071754
      Conserved Domains (1) summary
      cd22384
      Location:109 → 210
      KH-I_KHDRBS; type I K homology (KH) RNA-binding domain found in the KH domain-containing, RNA-binding, signal transduction-associated protein (KHDRBS) family

    3. NM_001299794.1 → NP_001286723.1  quaking related 58E-1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGB9, O44435
      Conserved Domains (1) summary
      cd02395
      Location:115 → 236
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG88 A0A0B4LG88
    A0A0B4LGB9 A0A0B4LGB9
    O44435 O44435
    Q9W255 Q9W255

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