C15 C15 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: C15provided by FlyBase
Official Full Name: C15provided by FlyBase
Primary source: FLYBASE:FBgn0004863
Locus tag: Dmel_CG7937
See related: AllianceGenome:FB:FBgn0004863
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 311; 93Bal; c15; CG7937; cll; Cll; Dmel\CG7937; Ect5; Hox11-311
Summary: Contributes to sequence-specific DNA binding activity. Involved in chaeta development; imaginal disc-derived appendage morphogenesis; and regulation of DNA-templated transcription. Part of protein-containing complex. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; cardiogenic mesoderm; epithelium; and ganglia. Human ortholog(s) of this gene implicated in adult T-cell leukemia/lymphoma. Orthologous to several human genes including TLX2 (T cell leukemia homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93E3-93E4; 3-72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21499986..21512814)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17325708..17338536)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we find that C15 interacts physically with the Dll activator through contacts between their homeodomain and binds competitively with Dll to adjacent cognate sites on LAE, adding potential new layers of regulation by C15. Lastly, we show that C15 and Bowl activities regulate also rn expression
Title: Tissue-specific enhancer repression through molecular integration of cell signaling inputs.
In the Al-Cll-DNA complex structure, the residues in the extended regions are used not only for the intermolecular contacts between the two homeodomain proteins but also for the sequence-recognition mechanism of DNA by direct interactions.
Title: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
Body patterning of legs is a product of this gene.
Title: Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15.
Data show that Aristaless and Clawless proteins form a complex capable of binding to specific DNA targets, which cannot be well recognized solely by Aristaless or Clawless.
Title: A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg.
Mutational analysis shows that the number of Smad- and Zen-binding sites is essential for the C15 transcriptional response, and the spatial limits of C15 expression are established through a repression mechanism in the dorsolateral cells of the embryo.
Title: Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in elongation of arista core	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: C15

Names: C15-PA; CG7937-PA; clawless

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21499986..21512814

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057525.3 → NP_476873.2 C15 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476873.2

Status: REVIEWED

UniProtKB/TrEMBL

Q4V729, Q7KS72

Related

FBpp0083510

Conserved Domains (2) summary

COG5576
Location:196 → 315

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:220 → 273

Homeobox; Homeobox domain