U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vps45 Vacuolar protein sorting 45 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41153, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Vps45provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 45provided by FlyBase
    Primary source
    FLYBASE:FBgn0261049
    Locus tag
    Dmel_CG8228
    See related
    AllianceGenome:FB:FBgn0261049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8228; Dmel\CG8228; DmVps45; dVps45; MENE (3R)-C; MENE(3R)-C; vps45; VPS45; Vps45p
    Summary
    Enables SNARE binding activity. Involved in endocytosis; endosomal vesicle fusion; and plasma membrane to endosome transport. Located in early endosome. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Vps45 in Genome Data Viewer
    Location:
    85D25-85D25; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9563924..9566092)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5389646..5391814)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Methyl-CpG binding domain protein-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Vesicle trafficking: pleasure and pain from SM genes. Toonen RF, et al. Trends Cell Biol, 2003 Apr. PMID 12667755
    2. Drosophila Strip serves as a platform for early endosome organization during axon elongation. Sakuma C, et al. Nat Commun, 2014 Oct 14. PMID 25312435, Free PMC Article
    3. Tethering complexes in the endocytic pathway: CORVET and HOPS. Solinger JA, et al. FEBS J, 2013 Jun. PMID 23351085
    4. Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin. Schottenfeld-Roames J, et al. Curr Biol, 2014 Aug 4. PMID 25065756, Free PMC Article
    5. Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Morrison HA, et al. Mol Biol Cell, 2008 Oct. PMID 18685079, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNARE binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in plasma membrane to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle priming NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    vacuolar protein sorting 45
    Names
    CG8228-PA
    Vps45-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9563924..9566092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141652.2 → NP_649909.1  vacuolar protein sorting 45 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHB5
      Related
      FBpp0081548
      Conserved Domains (1) summary
      pfam00995
      Location:23 → 543
      Sec1; Sec1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHB5 Q9VHB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous