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    TyrRS Tyrosyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TyrRSprovided by FlyBase
    Official Full Name
    Tyrosyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027080
    Locus tag
    Dmel_CG4561
    See related
    AllianceGenome:FB:FBgn0027080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-tyr; anon-EST:Posey261; CG4561; Dmel\CG4561; dTyrRS; dYARS; dYARS1; EMAP; YARS; YRS
    Summary
    Enables tyrosine-tRNA ligase activity. Predicted to be involved in tyrosyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; and organism. Used to study Charcot-Marie-Tooth disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TyrRS in Genome Data Viewer
    Location:
    72F1-72F1; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16417349..16419302, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16410449..16412402, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene failed axon connections Neighboring gene Serine incorporator Neighboring gene Glutamyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene doublesex cognate 73A Neighboring gene argos

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila as a platform to predict the pathogenicity of novel aminoacyl-tRNA synthetase mutations in CMT. Leitão-Gonçalves R, et al. Amino Acids, 2012 May. PMID 21384131
    2. Peripheral neuropathy via mutant tRNA synthetases: Inhibition of protein translation provides a possible explanation. Storkebaum E. Bioessays, 2016 Sep. PMID 27352040, Free PMC Article
    3. Drosophila Models for Charcot-Marie-Tooth Neuropathy Related to Aminoacyl-tRNA Synthetases. Morant L, et al. Genes (Basel), 2021 Sep 27. PMID 34680913, Free PMC Article
    4. The rarity of gene shuffling in conserved genes. Conant GC, et al. Genome Biol, 2005. PMID 15960802, Free PMC Article
    5. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Storkebaum E, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19561293, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling.
      Title: Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling.
    2. This study showed that show that apoptotic loser cells secrete Tyrosyl-tRNA synthetase, which is best known as a core component of the translational machinery.
      Title: Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition.
    3. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.
      Title: Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tyrosyl-tRNA synthetase
    Names
    CG4561-PA
    TyrRS-PA
    yars
    NP_648895.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16417349..16419302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140638.3 → NP_648895.1  Tyrosyl-tRNA synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV60
      Related
      FBpp0075168
      Conserved Domains (3) summary
      cd02799
      Location:364 → 466
      tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
      TIGR00234
      Location:12 → 332
      tyrS; tyrosyl-tRNA synthetase
      cl00015
      Location:8 → 334
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV60 Q9VV60

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