MtnA Metallothionein A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MtnAprovided by FlyBase
Official Full Name: Metallothionein Aprovided by FlyBase
Primary source: FLYBASE:FBgn0002868
Locus tag: Dmel_CG9470
See related: AllianceGenome:FB:FBgn0002868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.42; anon-WO0153538.44; anon-WO0153538.49; BcDNA:GH18460; CG9470; Dmel\CG9470; DrosMtn; MT; MTA; Mtn; MTN; mtna; mtnA
Summary: Enables metal ion binding activity. Involved in cellular detoxification of metal ion and response to metal ion. Is expressed in adult CNS glial cell and seminal receptacle. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85E8-85E9; 3-49 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9783407..9784370, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5609129..5610092, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results are consistent with the deletion being selectively favored in temperate populations due to the increased MtnA expression and oxidative stress tolerance that it confers.
Title: Population Genetic and Functional Analysis of a cis-Regulatory Polymorphism in the DrosophilamelanogasterMetallothionein A gene.
the 3' UTR deletion has been a target of selection for its ability to confer increased levels of MtnA expression in northern European populations, likely due to a local adaptive advantage of increased oxidative stress tolerance.
Title: An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster.
Data suggest a gene other than metallothionein may be involved in cadmium resistance.
Title: Decreased accumulation of cadmium in Drosophila selected for resistance suggests a mechanism independent of metallothionein.
Data indicate that MTF-1 is capable of binding to different regions of MtnA and Ctr1b genes depending on different metal stimulation.
Title: Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation.
MTO metal binding features were analyzed for comparison with MTN, the paralogous Drosophila metallothionein, and to classify MTO as either zinc- or copper-thionein.
Title: MTO: the second member of a Drosophila dual copper-thionein system.
the preferential protection against copper and cadmium toxicity by MtnA and MtnB, respectively, are the result of a combination of promoter preference and metal binding
Title: The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of metal ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metal ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to metal ion	ISS Inferred from Sequence or Structural Similarity more info	PubMed