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    alpha-Man-IIb alpha-Mannosidase class II b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Man-IIbprovided by FlyBase
    Official Full Name
    alpha-Mannosidase class II bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026616
    Locus tag
    Dmel_CG4606
    See related
    AllianceGenome:FB:FBgn0026616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-M-II; alpha-Man-II b; CG4606; dGMIIb; DM-GII.2; Dmel\CG4606; GM; GTD#24/1; Man'ase; ManII; ManIIb
    Summary
    Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and mannosyl-oligosaccharide 1,6-alpha-mannosidase activity. Involved in N-glycan processing; encapsulation of foreign target; and rhodopsin biosynthetic process. Located in endomembrane system. Is expressed in adult fat body and adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Man-IIb in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15804248..15824118)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11629970..11649840)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene non-specific lethal 1 Neighboring gene antisense RNA:CR45891 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45211 Neighboring gene recombination-defective Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 1,4-Dideoxy-1,4-imino-D- and L-lyxitol-based inhibitors bind to Golgi α-mannosidase II in different protonation forms. Kóňa J, et al. Org Biomol Chem, 2022 Nov 23. PMID 36322142, Free PMC Article
    2. Topological effects and binding modes operating with multivalent iminosugar-based glycoclusters and mannosidases. Brissonnet Y, et al. J Am Chem Soc, 2013 Dec 11. PMID 24224682
    3. 'Click chemistry' synthesis of 1-(α-D-mannopyranosyl)-1,2,3-triazoles for inhibition of α-mannosidases. Poláková M, et al. Carbohydr Res, 2015 Apr 10. PMID 25658064, Free PMC Article
    4. REC, a new member of the MCM-related protein family, is required for meiotic recombination in Drosophila. Matsubayashi H, et al. Genes Genet Syst, 2003 Oct. PMID 14676427
    5. The alpha-mannosidases: phylogeny and adaptive diversification. Gonzalez DS, et al. Mol Biol Evol, 2000 Feb. PMID 10677852

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosyl-oligosaccharide 1,6-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    alpha-Mannosidase class II b
    Names
    CG4606-PA
    CG4606-PB
    CG4606-PC
    alpha mannosidase IIb
    alpha-D-mannosidase
    alpha-Man-IIb-PA
    alpha-Man-IIb-PB
    alpha-Man-IIb-PC
    alpha-mannosidase
    alpha-mannosidase 2
    alpha-mannosidase-IIb
    golgi alpha-mannosidase IIb
    mannosidase II
    NP_001262614.1
    NP_001287341.1
    NP_650494.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15804248..15824118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142237.3 → NP_650494.2  alpha-Mannosidase class II b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650494.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97043, Q9VF33
      Related
      FBpp0082633
      Conserved Domains (4) summary
      PLN02701
      Location:148 → 1246
      PLN02701; alpha-mannosidase
      cd10809
      Location:167 → 514
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:813 → 1241
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:508 → 596
      Alpha-mann_mid; Alpha mannosidase, middle domain

    2. NM_001275685.1 → NP_001262614.1  alpha-Mannosidase class II b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97043, Q9VF33
      Conserved Domains (4) summary
      PLN02701
      Location:148 → 1246
      PLN02701; alpha-mannosidase
      cd10809
      Location:167 → 514
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:813 → 1241
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:508 → 596
      Alpha-mann_mid; Alpha mannosidase, middle domain

    3. NM_001300412.1 → NP_001287341.1  alpha-Mannosidase class II b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97043, Q9VF33
      Conserved Domains (4) summary
      PLN02701
      Location:148 → 1246
      PLN02701; alpha-mannosidase
      cd10809
      Location:167 → 514
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:813 → 1241
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:508 → 596
      Alpha-mann_mid; Alpha mannosidase, middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97043 O97043
    Q75WP2 Q75WP2
    Q8MSX9 Q8MSX9
    Q9VF33 Q9VF33

    Gene LinkOut

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