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    CG6962 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6962provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037958
    Locus tag
    Dmel_CG6962
    See related
    AllianceGenome:FB:FBgn0037958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6962
    Summary
    Predicted to enable sphingomyelin phosphodiesterase D activity. Predicted to be involved in ceramide biosynthetic process; glycerophospholipid catabolic process; and sphingomyelin catabolic process. Is expressed in adult head and organism. Orthologous to human SMPD4 (sphingomyelin phosphodiesterase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6962 in Genome Data Viewer
    Location:
    87A1-87A1; 3-51 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11879702..11882534, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7705424..7708256, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kynurenine aminotransferase Neighboring gene uncharacterized protein Neighboring gene shadow Neighboring gene uncharacterized protein Neighboring gene methuselah-like 5 Neighboring gene Dynein axonemal light intermediate chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Patel MV, et al. Dev Biol, 2016 Jun 1. PMID 26994946, Free PMC Article
    2. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Lee LA, et al. Dev Cell, 2005 Mar. PMID 15737938
    3. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article
    4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sphingomyelin phosphodiesterase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin phosphodiesterase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6962-PA
    NP_650124.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11879702..11882534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141867.4 → NP_650124.1  uncharacterized protein Dmel_CG6962 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGH0
      Related
      FBpp0081990
      Conserved Domains (1) summary
      pfam14724
      Location:21 → 720
      mit_SMPDase; Mitochondrial-associated sphingomyelin phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGH0 Q9VGH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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