Octalpha2R alpha2-adrenergic-like octopamine receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Octalpha2Rprovided by FlyBase
Official Full Name: alpha2-adrenergic-like octopamine receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0038653
Locus tag: Dmel_CG18208
See related: AllianceGenome:FB:FBgn0038653
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18208; Dmel\CG18208; DmOctalpha2R; Octalpha
Summary: Enables octopamine receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult central nervous system; adult octopaminergic neurons; antennal lobe; and organism subdivision. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; artery disease (multiple); attention deficit hyperactivity disorder; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A); ADRA2B (adrenoceptor alpha 2B); and ADRA2C (adrenoceptor alpha 2C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18799280..18849224, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14625002..14674946, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables octopamine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG18208-PA; CG18208-PB; CG18208-PC; Octalpha2R-PA; Octalpha2R-PB; Octalpha2R-PC; octopamine receptor

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The following sections contain reference sequences that belong to a specific genome build. Explain