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    CG6337 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6337provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033873
    Locus tag
    Dmel_CG6337
    See related
    AllianceGenome:FB:FBgn0033873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6337
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in adult head; embryonic Malpighian tubule; embryonic hindgut; and embryonic main segment of Malpighian tubule. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6337 in Genome Data Viewer
    Location:
    50C6-50C6; 2-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13833575..13835096, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9721080..9722601, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cathepsin L2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Kocks C, et al. Mol Cell Proteomics, 2003 Nov. PMID 13130081
    2. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Wang M, et al. Dev Cell, 2022 May 23. PMID 35512700
    3. Global analysis of patterns of gene expression during Drosophila embryogenesis. Tomancak P, et al. Genome Biol, 2007. PMID 17645804, Free PMC Article
    4. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Chaplot K, et al. Dis Model Mech, 2019 Feb 7. PMID 30635270, Free PMC Article
    5. Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis. Lebo MS, et al. BMC Genomics, 2009 Feb 13. PMID 19216785, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables cysteine-type peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6337-PA
    CG6337-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13833575..13835096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299466.1 → NP_001286395.1  uncharacterized protein Dmel_CG6337, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYA0
      Conserved Domains (2) summary
      cd02248
      Location:114 → 336
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:28 → 88
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    2. NM_137061.3 → NP_610905.1  uncharacterized protein Dmel_CG6337, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYA0
      Related
      FBpp0086772
      Conserved Domains (2) summary
      cd02248
      Location:114 → 336
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:28 → 88
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYA0 Q7JYA0

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