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    Rh2 Rhodopsin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rh2provided by FlyBase
    Official Full Name
    Rhodopsin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0003248
    Locus tag
    Dmel_CG16740
    See related
    AllianceGenome:FB:FBgn0003248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16740; Dm Rh2; DMELRH2; Dmel\CG16740; r2; Rh; rh2; RH2
    Summary
    Enables G protein-coupled photoreceptor activity. Involved in phototransduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; photoreceptor; rhabdomeric photoreceptor cell; and testis. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rh2 in Genome Data Viewer
    Location:
    91D4-91D4; 3-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18899423..18901019)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14725145..14726741)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted misexpression of a Drosophila opsin gene leads to altered visual function. Feiler R, et al. Nature, 1988 Jun 23. PMID 2455230
    2. An opsin gene expressed in only one photoreceptor cell type of the Drosophila eye. Cowman AF, et al. Cell, 1986 Mar 14. PMID 2936466
    3. Ectopic expression of a minor Drosophila opsin in the major photoreceptor cell class: distinguishing the role of primary receptor and cellular context. Zuker CS, et al. Cell, 1988 May 6. PMID 2966681
    4. Spectral tuning of rhodopsin and metarhodopsin in vivo. Britt SG, et al. Neuron, 1993 Jul. PMID 8338666
    5. Ectopic expression of ultraviolet-rhodopsins in the blue photoreceptor cells of Drosophila: visual physiology and photochemistry of transgenic animals. Feiler R, et al. J Neurosci, 1992 Oct. PMID 1403087, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homothorax controls a binary Rhodopsin switch in Drosophila ocelli.
      Title: Homothorax controls a binary Rhodopsin switch in Drosophila ocelli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phototransduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rhodopsin 2
    Names
    CG16740-PA
    Rh2-PA
    rhodopsin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18899423..18901019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079674.3 → NP_524398.1  rhodopsin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08099, Q9VE29
      UniProtKB/TrEMBL
      Q86P71, S5M1F0
      Related
      FBpp0083111
      Conserved Domains (2) summary
      pfam00001
      Location:74 → 336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:67 → 237
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08099.1 P08099
    Q86P71 Q86P71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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