Uba5 Ubiquitin-like activating enzyme 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Uba5provided by FlyBase
Official Full Name: Ubiquitin-like activating enzyme 5provided by FlyBase
Primary source: FLYBASE:FBgn0030305
Locus tag: Dmel_CG1749
See related: AllianceGenome:FB:FBgn0030305
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1749; Dmel\CG1749; dMoaD; dUBA5; MoeB
Summary: Predicted to enable UFM1 activating enzyme activity. Involved in neuromuscular process. Predicted to be active in cytosol. Is expressed in several structures, including adult brain; gland; glial cell; gut section; and head epidermis primordium. Used to study autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11483518..11485060)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11377551..11379093)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays.
Title: Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables UFM1 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables UFM1 activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ufmylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ufmylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain