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    CG1847 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1847provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030345
    Locus tag
    Dmel_CG1847
    See related
    AllianceGenome:FB:FBgn0030345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1847
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein maturation by protein folding and protein targeting to mitochondrion. Predicted to be located in cytosol. Is expressed in embryonic/larval crystal cell; organism; and procrystal cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; pituitary adenoma 1; and retinitis pigmentosa. Orthologous to several human genes including AIP (aryl hydrocarbon receptor interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1847 in Genome Data Viewer
    Location:
    10F2-10F2; 1-37 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11869170..11871168)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11763203..11765201)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ATP7 Neighboring gene Nardilysin Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo bioassay to test the pathogenicity of missense human AIP variants. Aflorei ED, et al. J Med Genet, 2018 Aug. PMID 29632148, Free PMC Article
    2. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. Ghartey-Kwansah G, et al. BMC Dev Biol, 2018 Mar 27. PMID 29587629, Free PMC Article
    3. shutdown is a component of the Drosophila piRNA biogenesis machinery. Preall JB, et al. RNA, 2012 Aug. PMID 22753781, Free PMC Article
    4. Cumulative contributions of weak DNA determinants to targeting the Drosophila dosage compensation complex. Gilfillan GD, et al. Nucleic Acids Res, 2007. PMID 17483514, Free PMC Article
    5. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1847-PA
    CG1847-PC
    CG1847-PD
    NP_001368980.1
    NP_572758.1
    NP_727574.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11869170..11871168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382046.1 → NP_001368980.1  uncharacterized protein Dmel_CG1847, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EG45
      Conserved Domains (3) summary
      TIGR00990
      Location:150 → 308
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:173 → 217
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:23 → 92
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. NM_132530.4 → NP_572758.1  uncharacterized protein Dmel_CG1847, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYT2
      Related
      FBpp0073411
      Conserved Domains (3) summary
      sd00006
      Location:173 → 217
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:23 → 92
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:173 → 254
      TPR_11; TPR repeat

    3. NM_167311.3 → NP_727574.2  uncharacterized protein Dmel_CG1847, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727574.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR85
      Conserved Domains (3) summary
      sd00006
      Location:173 → 217
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:23 → 92
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:173 → 254
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EG45 A0A6H2EG45
    Q8IR85 Q8IR85
    Q8SX17 Q8SX17
    Q9VYT2 Q9VYT2

    Gene LinkOut

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