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    Prx6a Peroxiredoxin 6a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prx6aprovided by FlyBase
    Official Full Name
    Peroxiredoxin 6aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031479
    Locus tag
    Dmel_CG3083
    See related
    AllianceGenome:FB:FBgn0031479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153181_at; CG3083; Dmel\CG3083; dPRDX6; dPRDX6-1; dPrx6b; DPx-6005; DPx6005; GM04269p; Prx6005
    Summary
    Enables peroxiredoxin activity. Involved in hydrogen peroxide catabolic process. Located in cytosol. Is expressed in adult head and organism. Orthologous to human PRDX6 (peroxiredoxin 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prx6a in Genome Data Viewer
    Location:
    23C1-23C1; 2-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2877091..2878232, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2877091..2878232, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Interferon-related developmental regulator 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene Sabbat Neighboring gene NTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The involvement of Importin-β and peroxiredoxin-6005 in mitochondrial biogenesis. Villanyi Z, et al. Mech Dev, 2011 Mar-Apr. PMID 21272635
    2. A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. Peterson TM, et al. Free Radic Biol Med, 2006 Mar 15. PMID 16540402, Free PMC Article
    3. The peroxiredoxin gene family in Drosophila melanogaster. Radyuk SN, et al. Free Radic Biol Med, 2001 Nov 1. PMID 11677042
    4. Beyond ROS clearance: Peroxiredoxins in stress signaling and aging. Detienne G, et al. Ageing Res Rev, 2018 Jul. PMID 29580920
    5. Peroxiredoxins are conserved markers of circadian rhythms. Edgar RS, et al. Nature, 2012 May 16. PMID 22622569, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. peroxiredoxin-6005 is engaged in mitochondrial biogenesis possibly as a component of redox-signaling
      Title: The involvement of Importin-β and peroxiredoxin-6005 in mitochondrial biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxiredoxin 6a
    Names
    CG3083-PA
    Prx6a-PA
    peroxiredoxin 6005
    NP_523463.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2877091..2878232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078739.3 → NP_523463.2  peroxiredoxin 6a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523463.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SB0, Q9GPQ2, Q9VQI7
      Related
      FBpp0077368
      Conserved Domains (2) summary
      COG0450
      Location:8 → 198
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03016
      Location:8 → 220
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SB0 Q95SB0
    Q9GPQ2 Q9GPQ2
    Q9VQI7 Q9VQI7

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