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    CG4842 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4842provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036620
    Locus tag
    Dmel_CG4842
    See related
    AllianceGenome:FB:FBgn0036620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4842
    Summary
    Predicted to enable alcohol dehydrogenase (NAD+) activity. Predicted to be involved in alcohol metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4842 in Genome Data Viewer
    Location:
    72E2-72E3; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16368389..16369518)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16361489..16362618)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 72Eb Neighboring gene Cuticular protein 72Ec Neighboring gene uncharacterized protein Neighboring gene roquin Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Hernández-Tobías A, et al. Chem Biol Interact, 2011 May 30. PMID 21329681
    2. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
    3. Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes. Chatterjee D, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25472843, Free PMC Article
    4. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article
    5. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in alcohol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4842-PA
    NP_648885.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16368389..16369518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140628.3 → NP_648885.1  uncharacterized protein Dmel_CG4842 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV47
      Related
      FBpp0075142
      Conserved Domains (2) summary
      pfam00106
      Location:6 → 194
      adh_short; short chain dehydrogenase
      cl21454
      Location:6 → 247
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV47 Q9VV47

    Gene LinkOut

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