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    Cdc5 Cell division cycle 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc5provided by FlyBase
    Official Full Name
    Cell division cycle 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0265574
    Locus tag
    Dmel_CG6905
    See related
    AllianceGenome:FB:FBgn0265574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdc5; cdc5-like; Cdc5Dm; cef1; CG6905; Dmel\CG6905
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Part of Prp19 complex. Is expressed in adult head and organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdc5 in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (357851..361383, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (357851..361383, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trachealess Neighboring gene long non-coding RNA:CR45378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Ohi R, et al. Mol Cell Biol, 1998 Jul. PMID 9632794, Free PMC Article
    2. A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation. Rylee J, et al. G3 (Bethesda), 2022 Nov 4. PMID 36218412, Free PMC Article
    3. Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons. Petruccelli E, et al. Genetics, 2020 May. PMID 32132098, Free PMC Article
    4. MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila. Klann M, et al. J Neurosci, 2021 Oct 6. PMID 34417328, Free PMC Article
    5. Wds-Mediated H3K4me3 Modification Regulates Lipid Synthesis and Transport in Drosophila. Zhao T, et al. Int J Mol Sci, 2023 Mar 24. PMID 37047100, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Prp19 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle 5
    Names
    CG6905-PA
    CG6905-PB
    Cdc5-PA
    Cdc5-PB
    cdc5
    cdc5-like
    cell division cycle 5 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      357851..361383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138189.3 → NP_612033.1  cell division cycle 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RL1, Q9W0R0
      Related
      FBpp0072468
      Conserved Domains (4) summary
      smart00717
      Location:8 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11659
      Location:56 → 108
      SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
      pfam11831
      Location:397 → 648
      Myb_Cef; pre-mRNA splicing factor component
      pfam13921
      Location:11 → 71
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    2. NM_001169842.2 → NP_001163313.1  cell division cycle 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RL1, Q9W0R0
      Conserved Domains (4) summary
      smart00717
      Location:8 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11659
      Location:56 → 108
      SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
      pfam11831
      Location:397 → 648
      Myb_Cef; pre-mRNA splicing factor component
      pfam13921
      Location:11 → 71
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0R0 Q9W0R0

    Gene LinkOut

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