Cox10 Cytochrome c oxidase assembly factor 10 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cox10provided by FlyBase
Official Full Name: Cytochrome c oxidase assembly factor 10provided by FlyBase
Primary source: FLYBASE:FBgn0032222
Locus tag: Dmel_CG5037
See related: AllianceGenome:FB:FBgn0032222
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5037; COXX; Dmel\CG5037
Summary: Predicted to enable protoheme IX farnesyltransferase activity. Predicted to be involved in heme A biosynthetic process and respiratory chain complex IV assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gastric caecum; and gut section. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10331471..10333129)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10331471..10333129)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protoheme IX farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protoheme IX farnesyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in respiratory chain complex IV assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_609382.1

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The following sections contain reference sequences that belong to a specific genome build. Explain