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    Gycbeta100B Guanylyl cyclase beta-subunit at 100B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gycbeta100Bprovided by FlyBase
    Official Full Name
    Guanylyl cyclase beta-subunit at 100Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013973
    Locus tag
    Dmel_CG1470
    See related
    AllianceGenome:FB:FBgn0013973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1470; Dgc beta 1; dgcb1; dgcbeta1; Dgcbeta1; Dmel\CG1470; Gbeta100B; gyc beta; Gycbeta-100B; gycbeta100B; sGC-beta; sGCbeta1; sGCbeta100B
    Summary
    Enables guanylate cyclase activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and response to oxygen levels. Part of guanylate cyclase complex, soluble. Is expressed in adult head and adult optic lobe. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gycbeta100B in Genome Data Viewer
    Location:
    100B4-100B5; 3-102 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31134392..31178278)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26960114..27004000)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46207 Neighboring gene long non-coding RNA:CR43458 Neighboring gene slow termination of phototransduction Neighboring gene mesh Neighboring gene bottleneck Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide-soluble guanylyl cyclase pathway as a contributor to age-related memory impairment in Drosophila. Tonoki A, et al. Aging Cell, 2022 Sep. PMID 35963012, Free PMC Article
    2. Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclase. Shah S, et al. J Biol Chem, 1995 Jun 23. PMID 7797526
    3. Modulation of the NO-cGMP pathway has no effect on olfactory responses in the Drosophila antenna. Prelic S, et al. Front Cell Neurosci, 2023. PMID 37305438, Free PMC Article
    4. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Wang L, et al. Nat Commun, 2015 Nov 26. PMID 26608817, Free PMC Article
    5. Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics. Aso Y, et al. Elife, 2019 Nov 14. PMID 31724947, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanylate cyclase complex, soluble IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylyl cyclase beta-subunit at 100B
    Names
    CG1470-PA
    Gycbeta100B-PA
    NP_524603.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31134392..31178278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079864.4 → NP_524603.2  guanylyl cyclase beta-subunit at 100B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524603.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24086, Q9VA09
      Related
      FBpp0085115
      Conserved Domains (4) summary
      smart00044
      Location:496 → 688
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:522 → 714
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:2 → 164
      HNOB; Haem-NO-binding
      pfam07701
      Location:326 → 516
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24086 Q24086
    Q9VA09 Q9VA09

    Gene LinkOut

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