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    thoc5 thoc5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thoc5provided by FlyBase
    Official Full Name
    thoc5provided by FlyBase
    Primary source
    FLYBASE:FBgn0034939
    Locus tag
    Dmel_CG2980
    See related
    AllianceGenome:FB:FBgn0034939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2980; Dmel\CG2980; garm; Thoc5; THOC5
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in male meiotic nuclear division. Located in nucleus. Part of THO complex. Colocalizes with nuclear chromosome and nucleolus. Is expressed in organism. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See thoc5 in Genome Data Viewer
    Location:
    60A13-60A13; 2-105 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23954091..23956406)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19841614..19843929)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Stomatin like 2 Neighboring gene fizzy-related 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha-catenin related Neighboring gene uncharacterized protein Neighboring gene Flavin-containing monooxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Moon S, et al. Mol Cells, 2013 Mar. PMID 23475424, Free PMC Article
    2. piRNA-independent transposon silencing by the Drosophila THO complex. Zhang G, et al. Dev Cell, 2021 Sep 27. PMID 34547226, Free PMC Article
    3. [Interactions of the TREX-2 complex with mRNP particle of β-tubulin 56D gene]. Popova VV, et al. Mol Biol (Mosk), 2016 Nov-Dec. PMID 28064320
    4. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
    5. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. Gurskiy DY, et al. Dokl Biochem Biophys, 2010 Jul-Aug. PMID 20714859

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flies lacking THOC5 showed a meiotic arrest phenotype with severe nucleolar disruption in primary spermatocytes.
      Title: The THO complex is required for nucleolar integrity in Drosophila spermatocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus in response to heat stress IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    thoc5
    Names
    CG2980-PA
    garmcho
    thoc5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23954091..23956406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138012.3 → NP_611856.1  thoc5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RL0, Q9W1F4
      Related
      FBpp0072056
      Conserved Domains (1) summary
      pfam09766
      Location:48 → 392
      FimP; Fms-interacting protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1F4.2 Q9W1F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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