Set1 SET domain containing 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Set1provided by FlyBase
Official Full Name: SET domain containing 1provided by FlyBase
Primary source: FLYBASE:FBgn0040022
Locus tag: Dmel_CG40351
See related: AllianceGenome:FB:FBgn0040022
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aaf45425 Dm; CG17395; CG17396; CG40351; Dmel\CG40351; dSet-1; dset1; dSet1; dSET1; l(3)h5; l5; set1; SET1; SetD1; SETD1
Summary: Enables histone H3K4 trimethyltransferase activity. Located in euchromatin and polytene chromosome. Part of Set1C/COMPASS complex. Is expressed in spermatozoon. Used to study neurodevelopmental disorder with speech impairment and dysmorphic facies. Human ortholog(s) of this gene implicated in early-onset epilepsy 2 and neurodevelopmental disorder with speech impairment and dysmorphic facies. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase) and SETD1B (SET domain containing 1B, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80F9-80F9; 3-47 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (25107594..25115180)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3LHet	NW_001848857.1 (593050..600636)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct Roles for COMPASS Core Subunits Set1, Trx, and Trr in the Epigenetic Regulation of Drosophila Heart Development.
Title: Distinct Roles for COMPASS Core Subunits Set1, Trx, and Trr in the Epigenetic Regulation of Drosophila Heart Development.
dBre1 interacts with dSet1 in controlling germline stem cells maintenance and germ cell differentiation.
Title: dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K4 trimethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	IDA Inferred from Direct Assay more info	PubMed
part_of Set1C/COMPASS complex	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SET domain containing 1

Names: CG40351-PA; CG40351-PB; CG40351-PC; CG40351-PD; CG40351-PE; CG40351-PF; CG40351-PG; CG40351-PH; CG40351-PI; SET domain-containing 1; Set1-PA; Set1-PB; Set1-PC; Set1-PD; Set1-PE; Set1-PF; Set1-PG; Set1-PH; Set1-PI; lethal 5; lethal5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

25107594..25115180

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170377.1 → NP_001163848.1 SET domain containing 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163848.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001110936.3 → NP_001104406.1 SET domain containing 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104406.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001015222.3 → NP_001015222.1 SET domain containing 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015222.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001170375.2 → NP_001163846.1 SET domain containing 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163846.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001170376.2 → NP_001163847.1 SET domain containing 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163847.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001170380.2 → NP_001163851.1 SET domain containing 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163851.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001015221.3 → NP_001015221.1 SET domain containing 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015221.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001170378.1 → NP_001163849.1 SET domain containing 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163849.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
NM_001170379.1 → NP_001163850.1 SET domain containing 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163850.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9WDY6, Q4V706, Q5LJZ2, Q8SXR9

Conserved Domains (6) summary

smart00317
Location:1504 → 1625

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:1463 → 1641

SET; SET domain-containing protein (function unknown) [General function prediction only]

cd12304
Location:99 → 191

RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases

pfam08648
Location:255 → 380

DUF1777; Protein of unknown function (DUF1777)

pfam11764
Location:1341 → 1492

N-SET; COMPASS (Complex proteins associated with Set1p) component N

pfam12871
Location:318 → 388

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term