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    Grip91 Gamma-tubulin ring protein 91 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grip91provided by FlyBase
    Official Full Name
    Gamma-tubulin ring protein 91provided by FlyBase
    Primary source
    FLYBASE:FBgn0001612
    Locus tag
    Dmel_CG10988
    See related
    AllianceGenome:FB:FBgn0001612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.197; CG10988; dd4; Dd4; Dgrip9; dGRIP91; Dgrip91; DGrip91; Dgrips91; Dmel\CG10988; GCP3; GRIP91; l(1)d deg-4; l(1)d.deg.-4; l(1)d.deg.4; l(1)dd4; l(1)G0122
    Summary
    Enables gamma-tubulin binding activity. Contributes to microtubule minus-end binding activity. Involved in male meiotic nuclear division; meiotic spindle organization; and mitotic spindle-templated microtubule nucleation. Part of gamma-tubulin ring complex and gamma-tubulin small complex. Colocalizes with centrosome and mitotic spindle. Is expressed in adult head. Orthologous to human TUBGCP3 (tubulin gamma complex component 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grip91 in Genome Data Viewer
    Location:
    12B4-12B4; 1-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13736570..13744683, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13630603..13638716, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mutagen-sensitive 101 Neighboring gene garnet Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42861 Neighboring gene Programmed cell death 4 Neighboring gene antisense RNA:CR43833

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional role of centrosomes in spindle assembly and organization. Varmark H. J Cell Biochem, 2004 Apr 1. PMID 15034926
    2. Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics. Malerød L, et al. EMBO J, 2018 Jul 2. PMID 29858227, Free PMC Article
    3. Gamma-tubulin complexes: size does matter. Jeng R, et al. Trends Cell Biol, 1999 Sep. PMID 10461186
    4. Distinct Dgrip84 isoforms correlate with distinct gamma-tubulins in Drosophila. Wiese C. Mol Biol Cell, 2008 Jan. PMID 18003974, Free PMC Article
    5. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. Oegema K, et al. J Cell Biol, 1999 Feb 22. PMID 10037793, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to microtubule minus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin small complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin small complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-tubulin ring protein 91
    Names
    CG10988-PA
    Dgrip91
    Dgrips91
    Grip91-PA
    lethal (1) discs degenerate 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13736570..13744683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080180.4 → NP_524919.2  Gamma-tubulin ring protein 91 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524919.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY94, Q9XYP8
      Related
      FBpp0073672
      Conserved Domains (1) summary
      pfam04130
      Location:236 → 758
      Spc97_Spc98; Spc97 / Spc98 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XYP8.2 Q9XYP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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