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    jing jing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jingprovided by FlyBase
    Official Full Name
    jingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086655
    Locus tag
    Dmel_CG9397
    See related
    AllianceGenome:FB:FBgn0086655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1.28; AEBP2; CG9397; CG9403; CT9093; Dmel\CG9397; Jing; l(2)01094; l(2)22F3
    Old locus tag
    CG9403; Dmel_CG9403
    Summary
    Involved in several processes, including nervous system development; regionalization; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; germ layer; gut section; head epidermis primordium; and segment. Orthologous to human AEBP2 (AE binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jing in Genome Data Viewer
    Location:
    42B1-42B2; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6502006..6621792)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2389511..2509297)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phospholipase D Neighboring gene long non-coding RNA:CR46075 Neighboring gene long non-coding RNA:CR45127 Neighboring gene long non-coding RNA:CR43905 Neighboring gene stable intronic sequence RNA CR46361 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 16kD subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The zinc finger transcription factor Jing is required for dendrite/axonal targeting in Drosophila antennal lobe development. Nair IS, et al. Dev Biol, 2013 Sep 1. PMID 23810656
    2. Migration on the borderline. Greaves S. Nat Cell Biol, 2001 Feb. PMID 11175759
    3. Identification and characterization of a gene activated by the deformed homeoprotein. Mahaffey JW, et al. Development, 1993 May. PMID 8104141
    4. Regulation by homeoproteins: a comparison of deformed-responsive elements. Pederson JA, et al. Genetics, 2000 Oct. PMID 11014815, Free PMC Article
    5. The jing gene is required for embryonic brain development in Drosophila [corrected]. Sedaghat Y, et al. Dev Genes Evol, 2002 Jul. PMID 12111212

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Jing acts as a key transcriptional control element in wiring of the circuitry in the developing olfactory sensory system in Drosophila
      Title: The zinc finger transcription factor Jing is required for dendrite/axonal targeting in Drosophila antennal lobe development.
    2. Study shows that jing is a direct downstream target of Trh/Tgo and that Vvl and Pnt are also involved in jing tracheal activation.
      Title: The Drosophila jing gene is a downstream target in the Trachealess/Tango tracheal pathway.
    3. Study demonstrates that jing is required for btl expression in the branching trachea and dominantly interacts with known regulators of btl expression, including the ETS and POU transcription factors, pointed, and drifter/ventral veinless, respectively.
      Title: Drosophila Jing is part of the breathless fibroblast growth factor receptor positive feedback loop.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 6526307-6526541 mobile_element_type = transposon:jockey2{}2281
    • Loc: 6539006-6539110 mobile_element_type = transposon:INE-1{}2229
    • Loc: 6570445-6570634 mobile_element_type = transposon:INE-1{}2232
    • Loc: 6579687-6579719 mobile_element_type = transposon:INE-1{}2347
    • Loc: 6579828-6584856 mobile_element_type = transposon:flea{}756

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in specification of segmental identity, maxillary segment IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in specification of segmental identity, maxillary segment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral midline development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    jing
    Names
    1.28
    CG9397-PD
    CG9397-PH
    CG9397-PI
    CG9397-PJ
    deformed
    jing-PD
    jing-PH
    jing-PI
    jing-PJ
    rhumba

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6502006..6621792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103730.2 → NP_001097200.1  jing, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY48
      Conserved Domains (1) summary
      sd00017
      Location:1411 → 1430
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_136371.3 → NP_610215.3  jing, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610215.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHC2
      Conserved Domains (1) summary
      sd00017
      Location:1153 → 1172
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001103729.2 → NP_001097199.1  jing, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6L6, Q7KHG2, Q95RE5, Q967Y2
      UniProtKB/TrEMBL
      E2QC63
      Conserved Domains (1) summary
      sd00017
      Location:1153 → 1172
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_206027.3 → NP_995749.2  jing, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995749.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6L6, Q7KHG2, Q95RE5, Q967Y2
      UniProtKB/TrEMBL
      E2QC63
      Conserved Domains (1) summary
      sd00017
      Location:1153 → 1172
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHC2 A0A0C4DHC2
    A8DY48 A8DY48
    E2QC63 E2QC63
    Q24300 Q24300
    Q7KHG2.1 Q7KHG2

    Gene LinkOut

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