mtSSB mitochondrial single stranded DNA-binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mtSSBprovided by FlyBase
Official Full Name: mitochondrial single stranded DNA-binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0010438
Locus tag: Dmel_CG4337
See related: AllianceGenome:FB:FBgn0010438
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0046/13; c3a; CG4337; Dmel\CG4337; DmmtSSB; dmtSSB; lopo; SSB; SSB_DROME
Summary: Enables single-stranded DNA binding activity. Involved in DNA replication and regulation of DNA-templated DNA replication. Located in mitochondrial chromosome. Is expressed in several structures, including adult head; adult heart; cuboidal/columnar epithelium; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16204194..16205250, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12029916..12030972, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The stimulatory effect of mtSSB on Pol gamma on these ssDNA templates is not species-specific.
Title: Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA.
mtSSB uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells
Title: Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial genome maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial genome maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-directed DNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Names: CG4337-PA; low power; mitochondrial single strand binding protein; mitochondrial single-stranded DNA-binding; mitochondrial single-stranded DNA-binding protein; mtSSB-PA

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