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    Arl4 ADP ribosylation factor-like 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43771, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Arl4provided by FlyBase
    Official Full Name
    ADP ribosylation factor-like 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0039889
    Locus tag
    Dmel_CG2219
    See related
    AllianceGenome:FB:FBgn0039889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    arl4; ARL4B; BcDNA:AT26185; CG 2219; CG2219; Dmel\CG2219; Q9V4B2
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Located in cleavage furrow. Is expressed in organism. Orthologous to several human genes including ARL4A (ADP ribosylation factor like GTPase 4A) and ARL4C (ADP ribosylation factor like GTPase 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arl4 in Genome Data Viewer
    Location:
    102A6-102A6; 4-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (177348..179389, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (197974..200015, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45198 Neighboring gene long non-coding RNA:CR46488 Neighboring gene ATP binding cassette subfamily D member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila. Lee DM, et al. PLoS One, 2015. PMID 26556630, Free PMC Article
    2. Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication. Pasqualato S, et al. EMBO Rep, 2002 Nov. PMID 12429613, Free PMC Article
    3. Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster. Podemski L, et al. Chromosoma, 2004 Jun. PMID 15185094
    4. The Drosophila Sec7 domain guanine nucleotide exchange factor protein Gartenzwerg localizes at the cis-Golgi and is essential for epithelial tube expansion. Armbruster K, et al. J Cell Sci, 2012 Mar 1. PMID 22349697
    5. Gene transposition as a cause of hybrid sterility in Drosophila. Masly JP, et al. Science, 2006 Sep 8. PMID 16960009

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP ribosylation factor-like 4
    Names
    Arl4-PA
    Arl4-PB
    Arl4-PC
    CG2219-PA
    CG2219-PB
    CG2219-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      177348..179389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258479.3 → NP_001245408.1  ADP ribosylation factor-like 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVM3
      Conserved Domains (1) summary
      cl21455
      Location:24 → 311
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001272118.1 → NP_001259047.1  ADP ribosylation factor-like 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MN60
      Conserved Domains (1) summary
      cl38936
      Location:22 → 95
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_143648.3 → NP_651905.1  ADP ribosylation factor-like 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4B2
      Related
      FBpp0088220
      Conserved Domains (1) summary
      cd04152
      Location:22 → 310
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVM3 H9XVM3
    L0MN60 L0MN60
    Q9V4B2 Q9V4B2

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