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    Targ1 Terminal ADP-ribose protein glycohydrolase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Targ1provided by FlyBase
    Official Full Name
    Terminal ADP-ribose protein glycohydrolase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0053054
    Locus tag
    Dmel_CG33054
    See related
    AllianceGenome:FB:FBgn0053054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10167; CG10517; CG33054; Dmel\CG33054; dTarg1
    Summary
    Predicted to enable ADP-ribosyl-[dinitrogen reductase] hydrolase activity; ADP-ribosylglutamate hydrolase activity; and purine nucleoside binding activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Targ1 in Genome Data Viewer
    Location:
    78C2-78C2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21197411..21202882, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21190511..21195982, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin Neighboring gene Terminal ADP-ribose protein glycohydrolase 3 Neighboring gene Terminal ADP-ribose protein glycohydrolase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Fontana P, et al. Nat Commun, 2023 Jun 2. PMID 37268618, Free PMC Article
    2. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
    3. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
    4. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
    5. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables purine nucleoside binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    terminal ADP-ribose protein glycohydrolase 1
    Names
    CG33054-PA
    CG33054-PB
    Targ1-PA
    Targ1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21197411..21202882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176376.2 → NP_788554.1  terminal ADP-ribose protein glycohydrolase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP69, Q9VP70
      Related
      FBpp0077973
      Conserved Domains (1) summary
      cd02901
      Location:8 → 137
      Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    2. NM_176375.2 → NP_788553.1  terminal ADP-ribose protein glycohydrolase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPU1
      Related
      FBpp0077972
      Conserved Domains (1) summary
      cd02901
      Location:28 → 153
      Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPU1 Q8IPU1
    Q9VP69 Q9VP69

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