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    ecd ecdysoneless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ecdprovided by FlyBase
    Official Full Name
    ecdysonelessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000543
    Locus tag
    Dmel_CG5714
    See related
    AllianceGenome:FB:FBgn0000543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5714; Dmel\CG5714; Ecd; ecd-1; ecd1; ecdl; l(3)62Db; l(3)ecd; l(3)ecd-1; l(3)ecd1
    Summary
    Enables snRNP binding activity. Involved in several processes, including chitin-based embryonic cuticle biosynthetic process; embryonic morphogenesis; and mushroom body development. Located in cytoplasm. Is expressed in several structures, including egg chamber; gonad; imaginal disc; nurse cell; and ring gland. Orthologous to human ECD (ecdysoneless cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ecd in Genome Data Viewer
    Location:
    62D4-62D4; 3-2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2263581..2265857, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2263581..2265857, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Elongator complex protein 5 Neighboring gene peptide O-xylosyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45829 Neighboring gene obstructor-I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental analysis of Ganaspis xanthopoda, a larval parasitoid of Drosophila melanogaster. Melk JP, et al. J Exp Biol, 1999 Jul. PMID 10377270
    2. Roles of ecdysone in Drosophila development. Garen A, et al. Proc Natl Acad Sci U S A, 1977 Nov. PMID 16592466, Free PMC Article
    3. Drosophila male courtship behavior is modulated by ecdysteroids. Ganter GK, et al. J Insect Physiol, 2011 Sep. PMID 21704633, Free PMC Article
    4. Alterations in development, behavior, and physiology in Drosophila larva that have reduced ecdysone production. Li H, et al. J Neurophysiol, 2001 Jan. PMID 11152710
    5. The expression of insecticide resistance-related cytochrome P450 forms is regulated by molting hormone in Drosophila melanogaster. Spiegelman VS, et al. Biochem Biophys Res Commun, 1997 Mar 17. PMID 9125169

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ecd promotes U5 snRNP maturation and Prp8 stability.
      Title: Ecd promotes U5 snRNP maturation and Prp8 stability.
    2. In Drosophila cells, Ecd directly interacts with core components of the U5 snRNP spliceosomal complex.
      Title: Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing.
    3. The transcription factor Grainy head and the steroid hormone ecdysone drive the production of two partially overlapping sets of cuticle factors.
      Title: The transcription factor Grainy head and the steroid hormone ecdysone cooperate during differentiation of the skin of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables snRNP binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysone biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval or pupal development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in progression of morphogenetic furrow involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to symbiont IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to symbiont IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ecdysoneless
    Names
    CG5714-PA
    ecd-PA
    ecdysone
    ecdysoneless1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2263581..2265857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139450.3 → NP_647707.1  ecdysoneless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647707.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W032
      Related
      FBpp0072781
      Conserved Domains (1) summary
      pfam07093
      Location:18 → 619
      SGT1; SGT1 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W032.1 Q9W032

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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