tin tinman [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tinprovided by FlyBase
Official Full Name: tinmanprovided by FlyBase
Primary source: FLYBASE:FBgn0004110
Locus tag: Dmel_CG7895
See related: AllianceGenome:FB:FBgn0004110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7895; Dmel\CG7895; DmNK-4; DROHOXHK4; DROHOXNK4; HOX; msh-2; msh2; NK-4; NK-4/msh-2; NK4; NK4/msh-2; NKX2.5; Tin; TIN; tin/NK4; Tinman
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including digestive tract development; gonadal mesoderm development; and heart development. Located in nucleus. Is expressed in several structures, including cardial cell; cardioblast; dorsal vessel; mesoderm; and visceral mesoderm derivative. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in aortic valve disease 2; congenital heart disease (multiple); congenital nongoitrous hypothyroidism 5; and heart conduction disease (multiple). Orthologous to human NKX2-3 (NK2 homeobox 3); NKX2-5 (NK2 homeobox 5); and NKX2-6 (NK2 homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93D9-93D9; 3-71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21378977..21381970)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17204699..17207692)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus.
Title: A bioinformatics screen reveals hox and chromatin remodeling factors at the Drosophila histone locus.
Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.
Title: Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.
Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur expression. By adding MEF2 alongside Tinman and Pannier, an expansion in expression of Hand and Sur was observed.
Title: The Drosophila Transcription Factors Tinman and Pannier Activate and Collaborate with Myocyte Enhancer Factor-2 to Promote Heart Cell Fate.
Findings provide mechanistic insight into the brake on myogenesis that occurs during mesoderm specification: twist and tin expression at early stages in turn activate the myogenic inhibitor Him; yet, once Twist or Tin levels decline at mid-embryogenesis, Him is no longer expressed in the mesoderm, and MEF2-dependent muscle differentiation can proceed.
Title: The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm.
Plasticity in Hox/PBC interaction modes is a common molecular strategy for shaping Hox transcriptional activities.
Title: Hox transcriptional specificity despite a single class of cofactors: are flexible interaction modes the key? Plasticity in Hox/PBC interaction modes as a common molecular strategy for shaping Hox transcriptional activities.
The enhancers active in the heart progenitor cells and the heart generally are dependent on tinman gene activity, whereas those active in non-cardiac mesoderm are often bound neutrally by Tinman
Title: Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures.
Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.
Title: Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.
Tin is a direct regulator of midline in fly heart development.
Title: Tinman is a direct activator of midline in the Drosophila dorsal vessel.
analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development
Title: A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development.
Data show that cell fate decisions in the dorsal and lateral Twi- and Tin-positive mesoderm of Drosophila melanogaster depend on the antagonistic action of the transcription factor Lame duck and the zinc finger homeodomain factor Zfh1.
Title: Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic anterior midgut (ectodermal) morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in gonad development	TAS Traceable Author Statement more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metamorphosis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in neuroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed