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    RpLP0 Ribosomal protein LP0 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40451, updated on 17-Dec-2024

    Summary

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    Official Symbol
    RpLP0provided by FlyBase
    Official Full Name
    Ribosomal protein LP0provided by FlyBase
    Primary source
    FLYBASE:FBgn0000100
    Locus tag
    Dmel_CG7490
    See related
    AllianceGenome:FB:FBgn0000100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ap3; AP3; Ape; CG7490; Dmel\CG7490; l(3)0154; l(3)01544; L10; LP0; p0; P0; P35; PO; RLA0; RPL P0; Rplp0; RpP0; RpPO
    Summary
    Enables calcium ion binding activity; class II DNA-(apurinic or apyrimidinic site) endonuclease activity; and magnesium ion binding activity. A structural constituent of ribosome. Involved in base-excision repair. Located in cytosolic ribosome; nuclear matrix; and nucleoplasm. Is expressed in adult head; adult heart; and organism. Orthologous to human RPLP0 (ribosomal protein lateral stalk subunit P0) and RPLP0P6 (ribosomal protein lateral stalk subunit P0 pseudogene 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpLP0 in Genome Data Viewer
    Location:
    79B2-79B2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22075867..22077487)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22068967..22070587)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 79 Neighboring gene male-specific opa containing gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila AP3, a presumptive DNA repair protein, is homologous to human ribosomal associated protein P0. Grabowski DT, et al. Nucleic Acids Res, 1991 Aug 11. PMID 1870984, Free PMC Article
    2. Drosophila apurinic/apyrimidinic DNA endonucleases. Characterization of mechanism of action and demonstration of a novel type of enzyme activity. Spiering AL, et al. J Biol Chem, 1986 Mar 5. PMID 2419327
    3. Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease. Kelley MR, et al. Mol Cell Biol, 1989 Mar. PMID 2471063, Free PMC Article
    4. Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity. Yacoub A, et al. Nucleic Acids Res, 1996 Nov 1. PMID 8932386, Free PMC Article
    5. Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes. Satterfield TF, et al. Hum Mol Genet, 2006 Aug 15. PMID 16835262

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embryo cytoplasms
      Title: Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables large ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosomal protein LP0
    Names
    60S ribosomal protein P0
    ACIDIC RIBOSOMAL PROTEIN LP0
    CG7490-PA
    CG7490-PB
    RpLP0-PA
    RpLP0-PB
    apurinic endonuclease 3
    ribosomal protein P0

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22075867..22077487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275273.1 → NP_001262202.1  ribosomal protein LP0, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19889, Q5BHX7, Q9VNV9
      UniProtKB/TrEMBL
      M9PG76
      Conserved Domains (3) summary
      cd05795
      Location:8 → 182
      Ribosomal_P0_L10e; Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk ...
      PTZ00135
      Location:1 → 275
      PTZ00135; 60S acidic ribosomal protein P0; Provisional
      pfam00428
      Location:232 → 285
      Ribosomal_60s; 60s Acidic ribosomal protein

    2. NM_079487.4 → NP_524211.1  ribosomal protein LP0, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524211.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19889, Q5BHX7, Q9VNV9
      UniProtKB/TrEMBL
      M9PG76
      Related
      FBpp0078134
      Conserved Domains (3) summary
      cd05795
      Location:8 → 182
      Ribosomal_P0_L10e; Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk ...
      PTZ00135
      Location:1 → 275
      PTZ00135; 60S acidic ribosomal protein P0; Provisional
      pfam00428
      Location:232 → 285
      Ribosomal_60s; 60s Acidic ribosomal protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG76 M9PG76
    P19889.1 P19889

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