Glo1 Glyoxalase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Glo1provided by FlyBase
Official Full Name: Glyoxalase 1provided by FlyBase
Primary source: FLYBASE:FBgn0283450
Locus tag: Dmel_CG1707
See related: AllianceGenome:FB:FBgn0283450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1707; Dmel\CG1707; glo1
Summary: Enables lactoylglutathione lyase activity. Involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione and regulation of insulin receptor signaling pathway. Predicted to be located in cytosol. Is expressed in adult head and organism. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7393546..7395932, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3281051..3283437, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables lactoylglutathione lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactoylglutathione lyase activity	IEA Inferred from Electronic Annotation more info
enables lactoylglutathione lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

NP_610270.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain