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    Dus2 Dihydrouridine synthase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dus2provided by FlyBase
    Official Full Name
    Dihydrouridine synthase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0030554
    Locus tag
    Dmel_CG1434
    See related
    AllianceGenome:FB:FBgn0030554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1434; Dmel\CG1434
    Summary
    Predicted to enable tRNA-dihydrouridine20 synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; antennal primordium; ganglia; gut section; and head epidermis primordium. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dus2 in Genome Data Viewer
    Location:
    12E5-12E5; 1-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14237988..14240152)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14132021..14134185)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene F box and leucine-rich-repeat gene 4 Neighboring gene mRNA-capping-enzyme Neighboring gene antisense RNA:CR46473 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
    2. Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila. Dobens LL, et al. Cancers (Basel), 2021 Feb 20. PMID 33672471, Free PMC Article
    3. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
    4. Chronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior. Kim CS, et al. J Radiat Res, 2015 May. PMID 25792464, Free PMC Article
    5. A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes. Na H, et al. RNA, 2016 Apr. PMID 26847261, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine20 synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA dihydrouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dihydrouridine synthase 2
    Names
    CG1434-PA
    CG1434-PB
    Dus2-PA
    Dus2-PB
    NP_001285237.1
    NP_572950.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14237988..14240152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298308.1 → NP_001285237.1  dihydrouridine synthase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0H3, Q9VY45
      Conserved Domains (4) summary
      COG0042
      Location:14 → 287
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      COG0571
      Location:317 → 461
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00048
      Location:395 → 457
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:25 → 266
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    2. NM_132722.3 → NP_572950.2  dihydrouridine synthase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572950.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0H3, Q9VY45
      Related
      FBpp0073720
      Conserved Domains (4) summary
      COG0042
      Location:14 → 287
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      COG0571
      Location:317 → 461
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00048
      Location:395 → 457
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:25 → 266
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0H3 Q7K0H3
    Q9VY45 Q9VY45

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