roq roquin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: roqprovided by FlyBase
Official Full Name: roquinprovided by FlyBase
Primary source: FLYBASE:FBgn0036621
Locus tag: Dmel_CG16807
See related: AllianceGenome:FB:FBgn0036621
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16807; Dmel\CG16807; NEST:bs21b12; Roq
Summary: Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytoplasmic stress granule. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval salivary gland. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1) and RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16370938..16378566, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16364038..16371666, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain