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    alien alien [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alienprovided by FlyBase
    Official Full Name
    alienprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013746
    Locus tag
    Dmel_CG9556
    See related
    AllianceGenome:FB:FBgn0013746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Alien; BcDNA:LD10463; CG9556; CH2; csn2; Csn2; CSN2; Dch2; DCH2; Dmel\CG9556
    Summary
    Enables nuclear receptor binding activity and transcription corepressor activity. Involved in several processes, including female germ-line stem cell population maintenance; germarium-derived cystoblast division; and male germ-line cyst encapsulation. Located in cytoplasm. Part of COP9 signalosome and repressor ecdysone receptor complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval intrasegmental apodeme; larval intersegmental apodeme; and mesoderm. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alien in Genome Data Viewer
    Location:
    29F7-29F7; 2-34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8993818..8997379, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8993818..8997379, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene rolling stone Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Trypsin 29F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The coregulator Alien. Papaioannou M, et al. Nucl Recept Signal, 2007 Nov 30. PMID 18174916, Free PMC Article
    2. Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. Maier D, et al. Gene Expr Patterns, 2006 Oct. PMID 16750940
    3. The proteasome regulatory particle subunit Rpn6 is required for Drosophila development and interacts physically with signalosome subunit Alien/CSN2. Lier S, et al. Gene, 2002 Oct 2. PMID 12426099
    4. The mesodermal expression of rolling stone (rost) is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein. Paululat A, et al. J Cell Biol, 1997 Jul 28. PMID 9230076, Free PMC Article
    5. Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Oron E, et al. Mol Syst Biol, 2007. PMID 17486136, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eclosion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of repressor ecdysone receptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alien
    Names
    CG9556-PA
    CG9556-PB
    CG9556-PD
    CG9556-PE
    COP9 complex homolog subunit 2
    alien-PA
    alien-PB
    alien-PD
    alien-PE
    d-Alien
    drosophila COP9 signalosome homolog 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8993818..8997379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273347.1 → NP_001260276.1  alien, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G9, Q8MSX8, Q94899, Q9V3Z0
      UniProtKB/TrEMBL
      M9PFB5
      Conserved Domains (2) summary
      COG5159
      Location:104 → 410
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:310 → 414
      PCI; PCI domain

    2. NM_078793.6 → NP_523517.1  alien, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G9, Q8MSX8, Q94899, Q9V3Z0
      UniProtKB/TrEMBL
      M9PFB5
      Related
      FBpp0089195
      Conserved Domains (2) summary
      COG5159
      Location:104 → 410
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:310 → 414
      PCI; PCI domain

    3. NM_001298842.1 → NP_001285771.1  alien, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G9, Q8MSX8, Q94899, Q9V3Z0
      UniProtKB/TrEMBL
      M9PFB5
      Conserved Domains (2) summary
      COG5159
      Location:104 → 410
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:310 → 414
      PCI; PCI domain

    4. NM_164843.3 → NP_723438.1  alien, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G9, Q8MSX8, Q94899, Q9V3Z0
      UniProtKB/TrEMBL
      M9PFB5
      Related
      FBpp0079381
      Conserved Domains (2) summary
      COG5159
      Location:104 → 410
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:310 → 414
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFB5 M9PFB5
    Q94899.2 Q94899

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