Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hrb98DEprovided by FlyBase
Official Full Name: Heterogeneous nuclear ribonucleoprotein at 98DEprovided by FlyBase
Primary source: FLYBASE:FBgn0001215
Locus tag: Dmel_CG9983
See related: AllianceGenome:FB:FBgn0001215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-E7Delta6; CG9983; Dmel\CG9983; E7Delta6; HDP(P9); hnRNP A2/B1; Hrb1; hrb98 de; Hrb98 de; hrb98de; hrb98DE; HRB98DE; Hrb98DE/Hrp38; HRB98DE/hrp38; hrp38; Hrp38; p9; Pen9
Summary: Enables mRNA 5'-UTR binding activity and sequence-specific DNA binding activity. Involved in several processes, including female germ-line stem cell population maintenance; positive regulation of translation; and regulation of RNA splicing. Located in nucleus and polytene chromosome puff. Part of ribonucleoprotein complex. Is expressed in several structures, including Y chromosome loop; adult brain; adult brain cell body rind; ganglia; and germline cell. Used to study myopathy and neurodegenerative disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with Paget disease of bone and frontotemporal dementia (multiple); and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 98D6-98D6; 3-96 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (28599834..28605777)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24425556..24431499)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results showed that Hrp38 represses Nanos translation, whereas its poly(ADP-ribosyl)ation relieves the repression effect, allowing restricted Nanos expression in the posterior germ plasm during oogenesis and early embryogenesis.
Title: Poly(ADP-Ribosyl)ation of hnRNP A1 Protein Controls Translational Repression in Drosophila.
findings suggest that Hrp38 and its association with poly(ADP-ribose) control germline stem cell self-renewal and oocyte localization by regulating DE-cadherin translation
Title: Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables poly(G) binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein at 98DE

Names: CG9983-PA; CG9983-PB; CG9983-PC; CG9983-PD; CG9983-PE; CG9983-PF; Hrb98DE-PA; Hrb98DE-PB; Hrb98DE-PC; Hrb98DE-PD; Hrb98DE-PE; Hrb98DE-PF; hnRNA-binding protein 1; s

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

28599834..28605777

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170370.2 → NP_733249.1 heterogeneous nuclear ribonucleoprotein at 98DE, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733249.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH29

Related

FBpp0084667

Conserved Domains (2) summary

cd12578
Location:31 → 108

RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:122 → 194

RRM_SF; RNA recognition motif (RRM) superfamily
NM_170371.2 → NP_733250.1 heterogeneous nuclear ribonucleoprotein at 98DE, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733250.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV67, E8NH29

Related

FBpp0084668

Conserved Domains (2) summary

cd12578
Location:27 → 104

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:118 → 190

RRM_SF; RNA recognition motif (RRM) superfamily
NM_079819.3 → NP_524543.1 heterogeneous nuclear ribonucleoprotein at 98DE, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524543.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P07909, Q24359, Q24360, Q99361, Q9VAU7, Q9VAU8

UniProtKB/TrEMBL

A4V3J5, E6PBW8

Related

FBpp0084669

Conserved Domains (2) summary

cd12578
Location:32 → 109

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:123 → 195

RRM_SF; RNA recognition motif (RRM) superfamily
NM_170374.2 → NP_733253.1 heterogeneous nuclear ribonucleoprotein at 98DE, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733253.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V3J6, E6PBW8

Related

FBpp0084672

Conserved Domains (2) summary

cd12578
Location:28 → 105

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:119 → 191

RRM_SF; RNA recognition motif (RRM) superfamily
NM_170372.2 → NP_733251.1 heterogeneous nuclear ribonucleoprotein at 98DE, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733251.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P07909, Q24359, Q24360, Q99361, Q9VAU7, Q9VAU8

UniProtKB/TrEMBL

A4V3J5, E6PBW8

Related

FBpp0084670

Conserved Domains (2) summary

cd12578
Location:32 → 109

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:123 → 195

RRM_SF; RNA recognition motif (RRM) superfamily
NM_170373.2 → NP_733252.1 heterogeneous nuclear ribonucleoprotein at 98DE, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733252.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V3J6, E6PBW8

Related

FBpp0084671

Conserved Domains (2) summary

cd12578
Location:28 → 105

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:119 → 191

RRM_SF; RNA recognition motif (RRM) superfamily