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    Prp38 pre-mRNA processing factor 38 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prp38provided by FlyBase
    Official Full Name
    pre-mRNA processing factor 38provided by FlyBase
    Primary source
    FLYBASE:FBgn0050342
    Locus tag
    Dmel_CG30342
    See related
    AllianceGenome:FB:FBgn0050342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30342; CG8054; Dmel\CG30342; dprp38; prp38
    Summary
    Involved in mRNA splicing, via spliceosome and regulation of G2/M transition of mitotic cell cycle. Part of protein-containing complex. Is expressed in larval midline neurons and organism. Orthologous to human PRPF38A (pre-mRNA processing factor 38A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prp38 in Genome Data Viewer
    Location:
    45A12-45A12; 2-60 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9143956..9145151)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5031461..5032656)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Tsoi H, et al. Hum Mol Genet, 2011 Oct 1. PMID 21725067
    2. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells. Klusza S, et al. PLoS One, 2013. PMID 24244416, Free PMC Article
    3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    4. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
    5. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-mRNA processing factor 38
    Names
    CG30342-PA
    Prp38-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9143956..9145151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136619.3 → NP_610463.2  pre-mRNA processing factor 38 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610463.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JVL3
      Related
      FBpp0087663
      Conserved Domains (1) summary
      pfam03371
      Location:10 → 172
      PRP38; PRP38 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVL3.1 Q7JVL3

    Gene LinkOut

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