U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nrd1 Nardilysin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32143, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nrd1provided by FlyBase
    Official Full Name
    Nardilysinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030344
    Locus tag
    Dmel_CG2025
    See related
    AllianceGenome:FB:FBgn0030344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2025; Dmel\CG2025; dNrd1; dNRD1
    Summary
    Enables protein folding chaperone. Involved in chaperone-mediated protein folding. Part of protein folding chaperone complex. Is active in mitochondrial matrix. Is expressed in adult head. Used to study neurodegenerative disease. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nrd1 in Genome Data Viewer
    Location:
    10F2-10F2; 1-37 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11864651..11868893, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11758684..11762926, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene p24-related-1 Neighboring gene uncharacterized protein Neighboring gene ATP7 Neighboring gene uncharacterized protein Neighboring gene BLOC-1 related complex subunit 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Building dialogues between clinical and biomedical research through cross-species collaborations. Chao HT, et al. Semin Cell Dev Biol, 2017 Oct. PMID 28579453, Free PMC Article
    2. Cumulative contributions of weak DNA determinants to targeting the Drosophila dosage compensation complex. Gilfillan GD, et al. Nucleic Acids Res, 2007. PMID 17483514, Free PMC Article
    3. Genetic strategies to tackle neurological diseases in fruit flies. Şentürk M, et al. Curr Opin Neurobiol, 2018 Jun. PMID 29128849, Free PMC Article
    4. Pathways to neurodegeneration: lessons learnt from unbiased genetic screens in Drosophila. Singhal N, et al. J Genet, 2018 Jul. PMID 30027908
    5. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila. Rosa-Ferreira C, et al. Biol Open, 2018 Sep 5. PMID 30115618, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein folding chaperone complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nardilysin
    Names
    CG2025-PA
    Nrd1-PA
    NP_572757.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11864651..11868893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132529.4 → NP_572757.2  nardilysin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572757.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U158, Q9VYT3
      Related
      FBpp0073438
      Conserved Domains (4) summary
      COG1025
      Location:54 → 1023
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:136 → 246
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:289 → 472
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:478 → 766
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U158 Q5U158
    Q8SZT9 Q8SZT9
    Q9VYT3 Q9VYT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools