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    Dhc98D Dynein heavy chain at 89D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43379, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhc98Dprovided by FlyBase
    Official Full Name
    Dynein heavy chain at 89Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013813
    Locus tag
    Dmel_CG1842
    See related
    AllianceGenome:FB:FBgn0013813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1842; dhc; Dhc; DHC; DHC6; Dmel\CG1842
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility. Is active in sperm flagellum. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Used to study obesity. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhc98D in Genome Data Viewer
    Location:
    98D2-98D3; 3-96 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28486953..28519398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24312675..24345120)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46106 Neighboring gene beaten path VI Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Papilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Justice AE, et al. Nat Genet, 2019 Mar. PMID 30778226, Free PMC Article
    2. A family of dynein genes in Drosophila melanogaster. Rasmusson K, et al. Mol Biol Cell, 1994 Jan. PMID 8186464, Free PMC Article
    3. mRNA localization mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis. Fingerhut JM, et al. J Cell Biol, 2020 Sep 7. PMID 32706373, Free PMC Article
    4. A force balance model of early spindle pole separation in Drosophila embryos. Cytrynbaum EN, et al. Biophys J, 2003 Feb. PMID 12547760, Free PMC Article
    5. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein heavy chain at 89D
    Names
    CG1842-PB
    CG1842-PC
    CG1842-PD
    Dhc98D-PB
    Dhc98D-PC
    Dhc98D-PD
    dynein-related heavy chain polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28486953..28519398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079817.3 → NP_524541.3  dynein heavy chain at 89D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524541.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAV5
      Conserved Domains (6) summary
      pfam03028
      Location:4374 → 5068
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:523 → 983
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1798 → 2201
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3658 → 3989
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:4017 → 4233
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:2338 → 2565
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001170288.1 → NP_001163759.1  dynein heavy chain at 89D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ04
      Conserved Domains (6) summary
      pfam03028
      Location:4367 → 5061
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:516 → 976
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1791 → 2194
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3651 → 3982
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:4010 → 4226
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:2331 → 2558
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001276107.1 → NP_001263036.1  dynein heavy chain at 89D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI48
      Conserved Domains (6) summary
      pfam03028
      Location:3739 → 4433
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:6 → 348
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1163 → 1566
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3023 → 3354
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3382 → 3598
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1703 → 1930
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI48 A0A0B4KI48
    E1JJ04 E1JJ04
    Q8IHA1 Q8IHA1
    Q9VAV5 Q9VAV5
    V9GZI5 V9GZI5

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