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    AMPdeam AMP deaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AMPdeamprovided by FlyBase
    Official Full Name
    AMP deaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052626
    Locus tag
    Dmel_CG32626
    See related
    AllianceGenome:FB:FBgn0052626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AMP deam; CG11058; CG11065; CG15762; CG32626; Dmel\CG32626
    Summary
    Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; epithelium; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AMPdeam in Genome Data Viewer
    Location:
    12C6-12C7; 1-46 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13830741..13845866, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13724774..13739899, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 93kD-1 Neighboring gene Ajuba LIM protein Neighboring gene maternal gene required for meiosis Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44655

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors. Leung HT, et al. Neuron, 2008 Jun 26. PMID 18579079, Free PMC Article
    2. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
    3. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab R, et al. Gene, 2001 Apr 4. PMID 11311551
    4. The Drosophila SET domain encoding gene dEset is essential for proper development. Stabell M, et al. Hereditas, 2006 Dec. PMID 17362353
    5. Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Chew SK, et al. Nature, 2009 Jul 2. PMID 19483676, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables AMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMP deaminase
    Names
    AMPdeam-PC
    AMPdeam-PE
    AMPdeam-PF
    AMPdeam-PG
    AMPdeam-PH
    AMPdeam-PI
    AMPdeam-PJ
    AMPdeam-PK
    AMPdeam-PL
    CG32626-PC
    CG32626-PE
    CG32626-PF
    CG32626-PG
    CG32626-PH
    CG32626-PI
    CG32626-PJ
    CG32626-PK
    CG32626-PL
    NP_001188588.1
    NP_001245659.1
    NP_001245660.1
    NP_001285233.1
    NP_001285234.1
    NP_572931.1
    NP_727739.3
    NP_727740.2
    NP_727741.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13830741..13845866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258730.2 → NP_001245659.1  AMP deaminase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245659.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDW2
      Conserved Domains (1) summary
      cl00281
      Location:148 → 183
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. NM_167384.3 → NP_727739.3  AMP deaminase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727739.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY76
      Conserved Domains (2) summary
      PLN03055
      Location:221 → 757
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:257 → 753
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    3. NM_001298304.1 → NP_001285233.1  AMP deaminase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEY5
      Conserved Domains (2) summary
      PLN03055
      Location:248 → 784
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:284 → 780
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    4. NM_167385.4 → NP_727740.2  AMP deaminase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727740.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4U3, Q76NQ9
      Conserved Domains (2) summary
      PLN03055
      Location:99 → 635
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:135 → 631
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    5. NM_167386.2 → NP_727741.3  AMP deaminase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727741.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q76NR0
      Conserved Domains (2) summary
      PLN03055
      Location:224 → 760
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:260 → 756
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    6. NM_001258731.2 → NP_001245660.1  AMP deaminase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQK3, M9NGE0
      Conserved Domains (2) summary
      PLN03055
      Location:148 → 763
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:263 → 759
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    7. NM_001298305.1 → NP_001285234.1  AMP deaminase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFA0
      Conserved Domains (2) summary
      PLN03055
      Location:236 → 772
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:272 → 768
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    8. NM_001201659.1 → NP_001188588.1  AMP deaminase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS55
      Conserved Domains (2) summary
      PLN03055
      Location:239 → 775
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:275 → 771
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    9. NM_132703.3 → NP_572931.1  AMP deaminase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961Q7
      Related
      FBpp0073664
      Conserved Domains (2) summary
      PLN03055
      Location:78 → 693
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:193 → 689
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0IQK3 D0IQK3
    M9MS55 M9MS55
    M9NDW2 M9NDW2
    Q76NQ9 Q76NQ9
    Q76NR0 Q76NR0
    Q961Q7 Q961Q7
    Q9VY76 Q9VY76
    X2JEY5 X2JEY5
    X2JFA0 X2JFA0

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