Tcs3 Threonyl-carbamoyl synthesis 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tcs3provided by FlyBase
Official Full Name: Threonyl-carbamoyl synthesis 3provided by FlyBase
Primary source: FLYBASE:FBgn0283681
Locus tag: Dmel_CG4933
See related: AllianceGenome:FB:FBgn0283681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4933; Dmel\CG4933; kae1; l(3)72Fb; tcs3
Summary: Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Involved in positive regulation of translational initiation and tRNA threonylcarbamoyladenosine modification. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Used to study Galloway-Mowat syndrome 3. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16351991..16353286)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16345091..16346386)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila kae1 and its partners are core factors in t6A biogenesis.
Title: An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N(6)-L-threonylcarbamoyladenine synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA threonylcarbamoyladenosine modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA threonylcarbamoyladenosine modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA threonylcarbamoyladenosine modification	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of EKC/KEOPS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EKC/KEOPS complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

Names: CG4933-PA; Tcs3-PA; black spot; lethal (3) 72Fb; tRNA adenosine(37) threonylcarbamoyltransferase complex, transferase subunit

NP_648880.1

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The following sections contain reference sequences that belong to a specific genome build. Explain