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    gpr-2 G-protein regulator 2 [ Caenorhabditis elegans ]

    Gene ID: 176318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpr-2
    Official Full Name
    G-protein regulator 2
    Primary source
    WormBase:WBGene00001689
    Locus tag
    CELE_C38C10.4
    See related
    AllianceGenome:WB:WBGene00001689
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Is expressed in P lineage cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (9391330..9393164, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene putative G-protein coupled receptor tkr-1 Neighboring gene putative transporter slc-17.2 Neighboring gene Mediator of RNA polymerase II transcription subunit 14 Neighboring gene Neuropeptide-Like Protein Neighboring gene Putative ATP-dependent RNA helicase T26G10.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The distribution of active force generators controls mitotic spindle position. Grill SW, et al. Science, 2003 Jul 25. PMID 12881570
    2. G protein regulator 1 (GPR-1) localizes to cortical sites of artificial mechanical indentation in Caenorhabditis elegans zygotes. Bringmann H. Cytoskeleton (Hoboken), 2012 Oct. PMID 22927044
    3. Codon adaptation-based control of protein expression in C. elegans. Redemann S, et al. Nat Methods, 2011 Mar. PMID 21278743
    4. Kinesin-5 acts as a brake in anaphase spindle elongation. Saunders AM, et al. Curr Biol, 2007 Jun 19. PMID 17580072, Free PMC Article
    5. Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Pecreaux J, et al. Curr Biol, 2006 Nov 7. PMID 17084695

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Four distinct in vivo phosphorylated LIN-5 residues were found to have critical functions in spindle positioning. Two of these residues form part of a 30 amino acid binding site for GPR-1, which we identified by reverse two-hybrid screening. These LIN-5 phosphorylations promote LIN-5-GPR-1/2 interaction and contribute to cortical pulling forces
      Title: Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans.
    2. Data demonstrate that GPB-1 depletion results in the loss of GPR-1/2 asymmetry during mitosis.
      Title: Polarity mediates asymmetric trafficking of the Gbeta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos.
    3. Dynamic localization of gpr-2 to cell cortex forces generation of domains during spindle positioning.
      Title: Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning.
    4. findings show that the GoLoco-containing proteins GPR-1 and GPR-2, as well as the Galpha subunits GOA-1 and GPA-16, were essential for generation of proper pulling forces in asymmetric spindle positioning
      Title: Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
    5. Data suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division.
      Title: RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in aster IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein regulator 2
    NP_499066.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9391330..9393164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066665.8 → NP_499066.1  G-protein regulator 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499066.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03569
      Conserved Domains (1) summary
      smart00390
      Location:424 → 445
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03569.1

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