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    nmad-1 DNA N6-methyl adenine demethylase [ Caenorhabditis elegans ]

    Gene ID: 175765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nmad-1
    Official Full Name
    DNA N6-methyl adenine demethylase
    Primary source
    WormBase:WBGene00017304
    Locus tag
    CELE_F09F7.7
    See related
    AllianceGenome:WB:WBGene00017304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables broad specificity oxidative DNA demethylase activity. Involved in several processes, including meiotic chromosome condensation; positive regulation of egg-laying behavior; and positive regulation of organelle organization. Predicted to be located in nucleus. Predicted to be active in contractile ring and midbody. Is expressed in several structures, including hypodermis; intestine; muscle cell; pharynx; and rectal gland cell. Orthologous to human ALKBH4 (alkB homolog 4, lysine demethylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nmad-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5553489..5554934, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene CRIB domain-containing protein Neighboring gene Ferritin Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Neighboring gene DNA-directed RNA polymerase subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Basis of Nucleic Acid Recognition and 6mA Demethylation by Caenorhabditis elegans NMAD-1A. Shang G, et al. Int J Mol Sci, 2024 Jan 5. PMID 38255759, Free PMC Article
    2. DNA Methylation on N6-Adenine in C. elegans. Greer EL, et al. Cell, 2015 May 7. PMID 25936839, Free PMC Article
    3. DNA methylation 6 mA and histone methylation involved in multi-/trans-generational reproductive effects in Caenorhabditis elegans induced by Atrazine. Yin J, et al. Ecotoxicol Environ Saf, 2023 Jan 1. PMID 36508798
    4. The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline. Wang SY, et al. PLoS Genet, 2019 Jul. PMID 31283754, Free PMC Article
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA N6-methyladenine demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables broad specificity oxidative DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in demethylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA N6-methyl adenine demethylase
    NP_741141.1
    • Confirmed by transcript evidence
    NP_741142.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5553489..5554934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171124.5 → NP_741141.1  DNA N6-methyl adenine demethylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MNT8, Q8MNT9
      Conserved Domains (1) summary
      cl21496
      Location:85 → 256
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. NM_171125.5 → NP_741142.1  DNA N6-methyl adenine demethylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MNT9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MNT9.1

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