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    nap-1 Nucleosome assembly protein 1-like 1 [ Caenorhabditis elegans ]

    Gene ID: 177636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nap-1
    Official Full Name
    Nucleosome assembly protein 1-like 1
    Primary source
    WormBase:WBGene00017075
    Locus tag
    CELE_D2096.8
    See related
    AllianceGenome:WB:WBGene00017075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and cholesterol binding activity. Predicted to be involved in nucleosome assembly. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including NAP1L1 (nucleosome assembly protein 1 like 1); NAP1L2 (nucleosome assembly protein 1 like 2); and NAP1L4 (nucleosome assembly protein 1 like 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nap-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (8377705..8379319, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene P-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene DDE-1 domain-containing protein;ELYS domain-containing protein;FA_FANCE domain-containing protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene PRA1 family protein Neighboring gene Neuropeptide-Like Protein Neighboring gene C6 domain-containing protein Neighboring gene GAR domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding. Sarkar P, et al. Biochemistry, 2019 Jan 15. PMID 30521320
    2. NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans. Cheong MC, et al. Cell Mol Life Sci, 2013 May. PMID 23255046, Free PMC Article
    3. spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Wen C, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11114162, Free PMC Article
    4. Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. Min J, et al. Nat Chem Biol, 2007 Jan. PMID 17115034
    5. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Dong MQ, et al. Science, 2007 Aug 3. PMID 17673661

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular characterization of NAP1 chaperoning activity toward histones H2A/H2B has been reported.
      Title: Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B.
    2. The role of NAP1 acidic domains in the histone binding.
      Title: Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding.
    3. Nematode sterol-binding protein 1 (NSBP-1), a homolog of nucleosome assembly protein 1 (NAP1) in mammals influences many biological processes mediated by insulin signaling, such as longevity, dauer formation, fat storage, and resistance to oxidative stress.
      Title: NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleosome assembly protein 1-like 1
    NP_501422.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8377705..8379319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069021.9 → NP_501422.1  Nucleosome assembly protein 1-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19007
      Conserved Domains (1) summary
      pfam00956
      Location:28 → 291
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein
    Heading Accession and Version

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