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    elb-1 Ubiquitin-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elb-1
    Official Full Name
    Ubiquitin-like domain-containing protein
    Primary source
    WormBase:WBGene00001235
    Locus tag
    CELE_Y41C4A.10
    See related
    AllianceGenome:WB:WBGene00001235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Part of Cul2-RING ubiquitin ligase complex. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elb-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (11718834..11719450, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF3105 domain-containing protein Neighboring gene Digestive organ expansion factor homolog Neighboring gene LITAF domain-containing protein Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II. Sasagawa Y, et al. Chromosome Res, 2005. PMID 15973501
    2. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. van Haaften G, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15326288, Free PMC Article
    3. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower CS, et al. J Biol Chem, 1999 May 7. PMID 10224134
    4. The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development. Merlet J, et al. Development, 2010 Nov. PMID 20978077, Free PMC Article
    5. A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Starostina NG, et al. Dev Cell, 2007 Jul. PMID 17609115, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elongin B (ELB1) and C (ELC1) form a stable complex, and that depletion of either gene product by RNA-mediated interference (RNAi) causes pronounced defects in the second meiotic division
      Title: Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of VCB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of VCB complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like domain-containing protein
    NP_499517.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11718834..11719450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067116.7 → NP_499517.1  Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECR7
      Conserved Domains (1) summary
      cl00155
      Location:4 → 118
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version

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