ast-1 Transcription factor ast-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ast-1
Official Full Name: Transcription factor ast-1
Primary source: WormBase:WBGene00020368
Locus tag: CELE_T08H4.3
See related: AllianceGenome:WB:WBGene00020368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including nematode pharynx morphogenesis; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in intestine; neurons; rectal gland cell; and retrovesicular ganglion. Human ortholog(s) of this gene implicated in blood platelet disease; hereditary lymphedema; myeloid leukemia; and thrombocytopenia. Orthologous to several human genes including FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ast-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (4127837..4135359, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies indicate that Loss- and gain-of-function studies defined ast-1 as necessary and sufficient for the induction and maintenance of the dopaminergic identity of these neurons.
Title: A passport to neurotransmitter identity.
AST-1 is specifically required for axon navigation in certain classes of interneurons
Title: AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T08H4.3 (e-PCR)
- UniSTS:322313

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor ast-1

NP_001022326.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4127837..4135359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027155.6 → NP_001022326.1 Transcription factor ast-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022326.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22355

Conserved Domains (1) summary

smart00413
Location:213 → 296

ETS; erythroblast transformation specific domain