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    ogdh-1 2-oxoglutarate dehydrogenase, mitochondrial;Transketolase-like pyrimidine-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ogdh-1
    Official Full Name
    2-oxoglutarate dehydrogenase, mitochondrial;Transketolase-like pyrimidine-binding domain-containing protein
    Primary source
    WormBase:WBGene00020679
    Locus tag
    CELE_T22B11.5
    See related
    AllianceGenome:WB:WBGene00020679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in protein folding. Located in mitochondrion. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Orthologous to several human genes including OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ogdh-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (4696979..4704011, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene N-acetylgalactosaminide beta-1,3-galactosyltransferase Neighboring gene AMOP domain-containing protein Neighboring gene ncRNA Neighboring gene COP9/Signalosome and eIF3 complex-shared subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screening strategy identifies novel regulators of the proteostasis network. Silva MC, et al. PLoS Genet, 2011 Dec. PMID 22242008, Free PMC Article
    2. Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response. Kim E, et al. Nat Commun, 2023 Jun 22. PMID 37349299, Free PMC Article
    3. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
    4. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    5. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. Zugasti O, et al. BMC Biol, 2016 Apr 29. PMID 27129311, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in generation of precursor metabolites and energy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-oxoglutarate dehydrogenase, mitochondrial;Transketolase-like pyrimidine-binding domain-containing protein
    NP_001368291.1
    • Confirmed by transcript evidence
    NP_500617.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4696979..4704011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068216.6 → NP_500617.1  2-oxoglutarate dehydrogenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500617.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61199
      Conserved Domains (5) summary
      PRK09404
      Location:51 → 1018
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:269 → 531
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:650 → 866
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:49 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:873 → 1017
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    2. NM_001380203.1 → NP_001368291.1  Transketolase-like pyrimidine-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC51
      Conserved Domains (1) summary
      PRK09404
      Location:1 → 791
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61199.2

    Gene LinkOut

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