unc-83 KASH domain-containing protein;Nuclear migration protein unc-83 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-83
Official Full Name: KASH domain-containing protein;Nuclear migration protein unc-83
Primary source: WormBase:WBGene00006815
Locus tag: CELE_W01A11.3
See related: AllianceGenome:WB:WBGene00006815
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables dynein light chain binding activity. Involved in several processes, including egg-laying behavior; protein localization to nuclear envelope; and vulval development. Located in nuclear outer membrane. Is expressed in several structures, including P1; P10; P11; anal depressor muscle; and reproductive system. Used to study Emery-Dreifuss muscular dystrophy. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-83 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 16

Sequence:: Chromosome: V; NC_003283.11 (6465065..6487883)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-83 acts as the cargo-specific adaptor between the outer nuclear membrane and the microtubule motors kinesin-1 and dynein
Title: UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.
Data support a model in which UNC-83 plays a central role in nuclear migration by acting to bridge the nuclear envelope and as a kinesin-1/Unc-116 cargo-specific adaptor so that motor-generated forces specifically move the nucleus as a single unit.
Title: UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration.
UNC-83 and UNC-84, the KASH and SUN domain proteins, bridge the nuclear envelope, connecting the nuclear lamina to cytoskeletal components.
Title: UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W01A11.3 (e-PCR)
- UniSTS:311071

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dynein light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	TAS Traceable Author Statement more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: KASH domain-containing protein;Nuclear migration protein unc-83

NP_001076749.1

Confirmed by transcript evidence

NP_001380084.1

Confirmed by transcript evidence

NP_001380085.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6465065..6487883

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083280.3 → NP_001076749.1 Nuclear migration protein unc-83 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23064, Q95WB6

Conserved Domains (1) summary

pfam04698
Location:175 → 348

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
NM_001392532.1 → NP_001380084.1 Nuclear migration protein unc-83 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q0PDL1
NM_001392533.1 → NP_001380085.1 KASH domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G8JYF1

Conserved Domains (1) summary

COG1196
Location:432 → 650

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]